Alpha1/BetaB Heteromeric Glycine Receptor in Strychnine-Bound State
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7tu9
Q-score: 0.521
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S
Nat Commun (2023) 14 pp. 1363- [ DOI: doi:10.1038/s41467-023-37106-7 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Strychnine (334 Da, Ligand)
- Glycine receptor beta subunit 2 (65 kDa, Protein from Danio rerio)
- Glycine receptor subunit alphaz1 (52 kDa, Protein from Danio rerio)
- 1,2-dimyristoyl-sn-glycero-3-phosphocholine (678 Da, Ligand)
- Zebrafish alpha1 betab heteromeric glycine receptor (250 kDa, Complex from Danio rerio)
Alpha1/BetaB Heteromeric Glycine Receptor in Glycine-Bound State
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7tvi
Q-score: 0.375
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S
Nat Commun (2023) 14 pp. 1363- [ DOI: doi:10.1038/s41467-023-37106-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine receptor beta subunit 2 (65 kDa, Protein from Danio rerio)
- Glycine receptor subunit alphaz1 (52 kDa, Protein from Danio rerio)
- Zebrafish alpha1 betab heteromeric glycine receptor (250 kDa, Complex from Danio rerio)
- Glycine (75 Da, Ligand)
Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8fe1
Q-score: 0.527
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S
Nat Commun (2023) 14 pp. 1363-1363 [ DOI: doi:10.1038/s41467-023-37106-7 Pubmed: 36914669 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside (875 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Glycine receptor beta subunit 2 (65 kDa, Protein from Danio rerio)
- Glycine receptor subunit alphaz1 (52 kDa, Protein from Danio rerio)
- Decane (142 Da, Ligand)
- Zebrafish alpha1 betab heteromeric glycine receptor (250 kDa, Complex from Danio rerio)
- 1,2-dimyristoyl-sn-glycero-3-phosphocholine (678 Da, Ligand)
- Glycine (75 Da, Ligand)
Full length alpha1 Glycine receptor in presence of 32uM Tetrahydrocannabinol
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7m6m
Q-score: 0.46
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- (6ar,10ar)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6h-benzo[c]chromen-1-ol (314 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 0.1mM Glycine
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 7m6n
Q-score: 0.508
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 0.1mM Glycine and 32uM Tetrahydrocannabinol
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 7m6o
Q-score: 0.481
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (6ar,10ar)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6h-benzo[c]chromen-1-ol (314 Da, Ligand)
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 1mM Glycine
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7m6p
Q-score: 0.424
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 1
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 7m6q
Q-score: 0.486
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (6ar,10ar)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6h-benzo[c]chromen-1-ol (314 Da, Ligand)
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 2
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 7m6r
Q-score: 0.369
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 3
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7m6s
Q-score: 0.355
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)