Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9bit
Q-score: 0.539
Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2024) 15 pp. 8755-8755 [ DOI: doi:10.1038/s41467-024-53096-6 Pubmed: 39384780 ]
- Cloxacillin (435 Da, Ligand)
- Solute carrier family 15 member 2 (82 kDa, Protein from Rattus norvegicus)
- Nanobody (Complex from Lama glama)
- Pept2 (Complex from Rattus norvegicus)
- Complex of the mammalian peptide transporter pept2 with nanobody and bound cloxacillin, pose 1 (Complex from Rattus norvegicus)
- Nanobody (14 kDa, Protein from Lama glama)
Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9biu
Q-score: 0.548
Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2024) 15 pp. 8755-8755 [ DOI: doi:10.1038/s41467-024-53096-6 Pubmed: 39384780 ]
- Cloxacillin (435 Da, Ligand)
- Complex of the mammalian peptide transporter pept2 with nanobody and bound cloxacillin, pose 2 (Complex from Rattus norvegicus)
- Solute carrier family 15 member 2 (82 kDa, Protein from Rattus norvegicus)
- Nanobody (Complex from Lama glama)
- Pept2 (Complex from Rattus norvegicus)
- Nanobody (14 kDa, Protein from Lama glama)
Cryo EM structure of System XC- in complex with glutamate
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7p9u
Q-score: 0.399
Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2021) 12 pp. 7147-7147 [ DOI: doi:10.1038/s41467-021-27414-1 Pubmed: 34880232 ]
- System xc- (Complex from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (69 kDa, Protein from Homo sapiens)
- Cystine/glutamate transporter (56 kDa, Protein from Homo sapiens)
Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7bc7
Q-score: 0.514
Parker JL, Deme JC, Kuteyi G, Wu Z, Huo J, Goldman ID, Owens RJ, Biggin PC, Lea SM, Newstead S
Nature (2021) 595 pp. 130-134 [ DOI: doi:10.1038/s41586-021-03579-z Pubmed: 34040256 ]
- Proton-coupled folate transporter (46 kDa, Complex from Gallus gallus)
- Nanobody (13 kDa, Protein from Lama glama)
- Proton-coupled folate transporter (51 kDa, Protein from Gallus gallus)
- Nanobody (12 kDa, Complex from Lama glama)
- 2-{4-[2-(2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid (427 Da, Ligand)
- Complex of the proton coupled folate transporter at ph 6.0 bound to pemetrexed (59 kDa, Complex)