Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8dto
Q-score: 0.465
Wiehe K, Saunders KO, Stalls V, Cain DW, Venkatayogi S, Martin Beem JS, Berry M, Evangelous T, Henderson R, Hora B, Xia SM, Jiang C, Newman A, Bowman C, Lu X, Bryan ME, Bal J, Sanzone A, Chen H, Eaton A, Tomai MA, Fox CB, Tam YK, Barbosa C, Bonsignori M, Muramatsu H, Alam SM, Montefiori DC, Williams WB, Pardi N, Tian M, Weissman D, Alt FW, Acharya P, Haynes BF
Cell Host Microbe (2024) 32 pp. 693-709.e7 [ DOI: doi:10.1016/j.chom.2024.04.006 Pubmed: 38670093 ]
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Mu89 heavy chain (14 kDa, Protein from Mus musculus)
- V3-glycan vaccine induced antibody mu89 in complex with ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t hiv env trimer (360 kDa, Complex from Homo sapiens)
- Mu89 light chain (10 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp141 (17 kDa, Protein from Human immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 8dy6
Q-score: 0.355
Wiehe K, Saunders KO, Stalls V, Cain DW, Venkatayogi S, Martin Beem JS, Berry M, Evangelous T, Henderson R, Hora B, Xia SM, Jiang C, Newman A, Bowman C, Lu X, Bryan ME, Bal J, Sanzone A, Chen H, Eaton A, Tomai MA, Fox CB, Tam YK, Barbosa C, Bonsignori M, Muramatsu H, Alam SM, Montefiori DC, Williams WB, Pardi N, Tian M, Weissman D, Alt FW, Acharya P, Haynes BF
Cell Host Microbe (2024) 32 pp. 693-709.e7 [ DOI: doi:10.1016/j.chom.2024.04.006 Pubmed: 38670093 ]
- V3-glycan vaccine induced antibody mu89+s27y in complex with ch848.d949.10.17_n133d_n138t.ds.sosip.664 hiv env trimer (360 kDa, Complex from Human immunodeficiency virus 1)
- Mu89+s27y light chain (11 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp160 (72 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mu89+s27y heavy chain (16 kDa, Protein from Mus musculus)
Zika Virus particle bound with IgM antibody DH1017 Fab fragment
Resolution: 5.26 Å
EM Method: Single-particle
Fitted PDBs: 7t17
Q-score: 0.264
Singh T, Hwang KK, Miller AS, Jones RL, Lopez CA, Dulson SJ, Giuberti C, Gladden MA, Miller I, Webster HS, Eudailey JA, Luo K, Von Holle T, Edwards RJ, Valencia S, Burgomaster KE, Zhang S, Mangold JF, Tu JJ, Dennis M, Alam SM, Premkumar L, Dietze R, Pierson TC, Ooi EE, Lazear HM, Kuhn RJ, Permar SR, Bonsignori M
Cell (2022) 185 pp. 4826-4840.e17 [ DOI: doi:10.1016/j.cell.2022.10.023 Pubmed: 36402135 ]
- Core protein (42 kDa, Protein from Zika virus)
- Zika virus (Virus from Zika virus)
- Dh1017.igm fabc constant domain (10 kDa, Protein from Homo sapiens)
- Dh1017.igm igl (11 kDa, Protein from Homo sapiens)
- Dh1017.igm igh (13 kDa, Protein from Homo sapiens)
- Dh1017.igm lambdac constant domain (11 kDa, Protein from Homo sapiens)
Cryo-EM map of DH851.3 bound to HIV-1 CH505 Env
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7lu9
Q-score: 0.22
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Dh851.3 heavy chain (23 kDa, Protein from Macaca mulatta)
- Dh851.3 bound to hiv-1 ch505 env (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh851.3 heavy chain (24 kDa, Protein from Macaca mulatta)
- Dh851.3 light chain (22 kDa, Protein from Macaca mulatta)
- Dh851.3 light chain (21 kDa, Protein from Macaca mulatta)
Cryo-EM map of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7lua
Q-score: 0.267
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
- Dh898.1 heavy chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of dh898.1 fab-dimer bound near the cd4 binding site of hiv-1 env ch848 sosip trimer. (Complex from Human immunodeficiency virus 1)
- Env polyprotein (16 kDa, Protein from Simian-Human immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh898.1 light chain (23 kDa, Protein from Homo sapiens)
- Ch848 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
CON-S ch.ds.SOSIP HIV trimer bound to DH840 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH842 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH845 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH846 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Manne K, Stalls V, Hsu AL, Borgnia MJ, Stewart-Jones G, Lee MS, Bronkema N, Perfect J, Moody MA, Wiehe K, Bradley T, Kepler TB, Alam SM, Foulger A, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelso G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
bioRxiv (2020) https://doi.org/10.1101/2020.06.30.178921 [ DOI: doi:10.1101/2020.06.30.178921 ]
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 (Protein from Human immunodeficiency virus 1)
- Antibody dh898.1 fragment antigen binding (fab) light chain (Protein from Macaca mulatta)
- Antibody dh898.1 fragment antigen binding (fab) dimer (Complex from Macaca mulatta)
- Antibody dh898.1 fragment antigen binding (fab) heavy chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Antibody dh898.1 fab-dimer bound near the cd4 binding site of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (94 kDa, Complex)