Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8dto
Q-score: 0.465
Wiehe K, Saunders KO, Stalls V, Cain DW, Venkatayogi S, Martin Beem JS, Berry M, Evangelous T, Henderson R, Hora B, Xia SM, Jiang C, Newman A, Bowman C, Lu X, Bryan ME, Bal J, Sanzone A, Chen H, Eaton A, Tomai MA, Fox CB, Tam YK, Barbosa C, Bonsignori M, Muramatsu H, Alam SM, Montefiori DC, Williams WB, Pardi N, Tian M, Weissman D, Alt FW, Acharya P, Haynes BF
Cell Host Microbe (2024) 32 pp. 693-709.e7 [ DOI: doi:10.1016/j.chom.2024.04.006 Pubmed: 38670093 ]
- Mu89 heavy chain (14 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- V3-glycan vaccine induced antibody mu89 in complex with ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t hiv env trimer (360 kDa, Complex from Homo sapiens)
- Mu89 light chain (10 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp141 (17 kDa, Protein from Human immunodeficiency virus)
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 8dy6
Q-score: 0.355
Wiehe K, Saunders KO, Stalls V, Cain DW, Venkatayogi S, Martin Beem JS, Berry M, Evangelous T, Henderson R, Hora B, Xia SM, Jiang C, Newman A, Bowman C, Lu X, Bryan ME, Bal J, Sanzone A, Chen H, Eaton A, Tomai MA, Fox CB, Tam YK, Barbosa C, Bonsignori M, Muramatsu H, Alam SM, Montefiori DC, Williams WB, Pardi N, Tian M, Weissman D, Alt FW, Acharya P, Haynes BF
Cell Host Microbe (2024) 32 pp. 693-709.e7 [ DOI: doi:10.1016/j.chom.2024.04.006 Pubmed: 38670093 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mu89+s27y light chain (11 kDa, Protein from Mus musculus)
- V3-glycan vaccine induced antibody mu89+s27y in complex with ch848.d949.10.17_n133d_n138t.ds.sosip.664 hiv env trimer (360 kDa, Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (72 kDa, Protein from Human immunodeficiency virus 1)
- Mu89+s27y heavy chain (16 kDa, Protein from Mus musculus)
Cryo-EM map of DH851.3 bound to HIV-1 CH505 Env
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7lu9
Q-score: 0.22
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh851.3 bound to hiv-1 ch505 env (Complex from Human immunodeficiency virus 1)
- Dh851.3 heavy chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dh851.3 light chain (21 kDa, Protein from Macaca mulatta)
- Dh851.3 light chain (22 kDa, Protein from Macaca mulatta)
- Dh851.3 heavy chain (24 kDa, Protein from Macaca mulatta)
Cryo-EM map of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7lua
Q-score: 0.267
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Ch848 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Env polyprotein (16 kDa, Protein from Simian-Human immunodeficiency virus)
- Cryo-em structure of dh898.1 fab-dimer bound near the cd4 binding site of hiv-1 env ch848 sosip trimer. (Complex from Human immunodeficiency virus 1)
- Dh898.1 heavy chain (23 kDa, Protein from Homo sapiens)
- Dh898.1 light chain (23 kDa, Protein from Homo sapiens)
Cryo-electron microcospy reconstruction of CH848.3.D0949.10.17chim.6R.DS.SOSIP.664 HIV Env
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7l6o
Q-score: 0.426
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664 - gp120 (Protein from Human immunodeficiency virus 1)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 unliganded trimer in the presence of but not bound to dh898.1 fab (209 kDa, Complex from Human immunodeficiency virus 1)
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664 - gp41 (Protein from Human immunodeficiency virus 1)
Cryo-electron microscopy reconstruction of locally refined antibody DH898.1 Fab-dimer
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7l6m
Q-score: 0.267
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7l02
Q-score: 0.341
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex)
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex from Severe acute respiratory syndrome-related coronavirus)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to two copies of domain-swapped antibody 2G12
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7l06
Q-score: 0.303
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex from Homo sapiens)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7l09
Q-score: 0.365
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex from Homo sapiens)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6uda
Q-score: 0.325
LaBranche CC, Henderson R, Hsu A, Behrens S, Chen X, Zhou T, Wiehe K, Saunders KO, Alam SM, Bonsignori M, Borgnia MJ, Sattentau QJ, Eaton A, Greene K, Gao H, Liao HX, Williams WB, Peacock J, Tang H, Perez LG, Edwards RJ, Kepler TB, Korber BT, Kwong PD, Mascola JR, Acharya P, Haynes BF, Montefiori DC
PLoS Pathog (2019) 15 pp. e1008026-e1008026 [ DOI: doi:10.1371/journal.ppat.1008026 Pubmed: 31527908 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch505.n279k.g458y.sosip.664 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Ch235 uca heavy chain fab (26 kDa, Protein from Homo sapiens)
- Ch235 uca light chain fab (25 kDa, Protein from Homo sapiens)
- Complex of the ch235 unmutated common ancestor (uca) bound to man5-enriched ch505.n279k.g458y.sosip.664 (360 kDa, Complex from Human immunodeficiency virus 1)
- Ch505.n279k.g458y.sosip.664 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)