CON-S ch.ds.SOSIP HIV trimer bound to DH840 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH842 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH845 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH846 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6um5
Q-score: 0.347
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- Ch848 10.17 dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dh270 uca3 fab bound to hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- Dh270 uca3 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Dh270 uca3 fab light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6um6
Q-score: 0.318
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- Dh270.6 heavy chain (25 kDa, Protein from Homo sapiens)
- Dh270.6 light chain (22 kDa, Protein from Homo sapiens)
- Ch848 10.17dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17dt gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Complex of antibody dh270.6 with hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6um7
Q-score: 0.301
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ Pubmed: 31806786 DOI: doi:10.1126/science.aay7199 ]
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.mu1 fab heavy chain (26 kDa, Protein from Homo sapiens)
- Complex of dh270.mu1 and ch848 10.17dt envelope (360 kDa, Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270.mu1 fab light chain (24 kDa, Protein from Homo sapiens)
CH505 SOSIP.664 trimer in complex with DH522.2 Fab
Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, Saunders KO, Parks R, Foulger A, Xia SM, Bonsignori M, Montefiori DC, Louder M, Eaton A, Santra S, Scearce R, Sutherland L, Newman A, Bouton-Verville H, Bowman C, Bomze H, Gao F, Marshall DJ, Whitesides JF, Nie X, Kelsoe G, Reed SG, Fox CB, Clary K, Koutsoukos M, Franco D, Mascola JR, Harrison SC, Haynes BF, Verkoczy L
Nat Commun (2017) 8 pp. 1732-1732 [ DOI: doi:10.1038/s41467-017-01336-3 Pubmed: 29170366 ]
- Dh522.2 fab light chain (Macromolecule from Homo sapiens)
- Ch505 sosip.664 in complex with dh522.2 fab (Complex)
- Dh522.2 fab heavy chain (Macromolecule from Homo sapiens)
- Dh522.2 fab (Complex from Homo sapiens)
- Ch505 sosip.664 (Macromolecule from Human immunodeficiency virus 1)
- Ch505 sosip.664 (Complex from Homo sapiens)