Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8dto
Q-score: 0.465
Wiehe K, Saunders KO, Stalls V, Cain DW, Venkatayogi S, Martin Beem JS, Berry M, Evangelous T, Henderson R, Hora B, Xia SM, Jiang C, Newman A, Bowman C, Lu X, Bryan ME, Bal J, Sanzone A, Chen H, Eaton A, Tomai MA, Fox CB, Tam YK, Barbosa C, Bonsignori M, Muramatsu H, Alam SM, Montefiori DC, Williams WB, Pardi N, Tian M, Weissman D, Alt FW, Acharya P, Haynes BF
Cell Host Microbe (2024) 32 pp. 693-709.e7 [ DOI: doi:10.1016/j.chom.2024.04.006 Pubmed: 38670093 ]
- Mu89 heavy chain (14 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- V3-glycan vaccine induced antibody mu89 in complex with ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t hiv env trimer (360 kDa, Complex from Homo sapiens)
- Mu89 light chain (10 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp141 (17 kDa, Protein from Human immunodeficiency virus)
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 8dy6
Q-score: 0.355
Wiehe K, Saunders KO, Stalls V, Cain DW, Venkatayogi S, Martin Beem JS, Berry M, Evangelous T, Henderson R, Hora B, Xia SM, Jiang C, Newman A, Bowman C, Lu X, Bryan ME, Bal J, Sanzone A, Chen H, Eaton A, Tomai MA, Fox CB, Tam YK, Barbosa C, Bonsignori M, Muramatsu H, Alam SM, Montefiori DC, Williams WB, Pardi N, Tian M, Weissman D, Alt FW, Acharya P, Haynes BF
Cell Host Microbe (2024) 32 pp. 693-709.e7 [ DOI: doi:10.1016/j.chom.2024.04.006 Pubmed: 38670093 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mu89+s27y light chain (11 kDa, Protein from Mus musculus)
- V3-glycan vaccine induced antibody mu89+s27y in complex with ch848.d949.10.17_n133d_n138t.ds.sosip.664 hiv env trimer (360 kDa, Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (72 kDa, Protein from Human immunodeficiency virus 1)
- Mu89+s27y heavy chain (16 kDa, Protein from Mus musculus)
CON-S ch.ds.SOSIP HIV trimer bound to DH840 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH842 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH845 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
CON-S ch.DS.SOSIP HIV trimer bound to DH846 Fab
Cai F, Chen WH, Wu W, Jones J, Misook C, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Hernandez G, Nelson RW, Scearce R, Seaman M, Moody MA, Santra S, Wiehe KJ, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce GM, Saunders KO
To Be Published
Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6um5
Q-score: 0.347
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270 uca3 fab bound to hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17 dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Dh270 uca3 fab light chain (22 kDa, Protein from Homo sapiens)
- Dh270 uca3 fab heavy chain (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6um6
Q-score: 0.318
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270.6 heavy chain (25 kDa, Protein from Homo sapiens)
- Complex of antibody dh270.6 with hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- Ch848 10.17dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17dt gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.6 light chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6um7
Q-score: 0.301
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.mu1 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.mu1 fab light chain (24 kDa, Protein from Homo sapiens)
- Complex of dh270.mu1 and ch848 10.17dt envelope (360 kDa, Complex from Human immunodeficiency virus 1)
Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6uda
Q-score: 0.325
LaBranche CC, Henderson R, Hsu A, Behrens S, Chen X, Zhou T, Wiehe K, Saunders KO, Alam SM, Bonsignori M, Borgnia MJ, Sattentau QJ, Eaton A, Greene K, Gao H, Liao HX, Williams WB, Peacock J, Tang H, Perez LG, Edwards RJ, Kepler TB, Korber BT, Kwong PD, Mascola JR, Acharya P, Haynes BF, Montefiori DC
PLoS Pathog (2019) 15 pp. e1008026-e1008026 [ DOI: doi:10.1371/journal.ppat.1008026 Pubmed: 31527908 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch505.n279k.g458y.sosip.664 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Ch235 uca heavy chain fab (26 kDa, Protein from Homo sapiens)
- Ch235 uca light chain fab (25 kDa, Protein from Homo sapiens)
- Complex of the ch235 unmutated common ancestor (uca) bound to man5-enriched ch505.n279k.g458y.sosip.664 (360 kDa, Complex from Human immunodeficiency virus 1)
- Ch505.n279k.g458y.sosip.664 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)