Cryo-EM map of DH851.3 bound to HIV-1 CH505 Env
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7lu9
Q-score: 0.22
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh851.3 bound to hiv-1 ch505 env (Complex from Human immunodeficiency virus 1)
- Dh851.3 heavy chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dh851.3 light chain (21 kDa, Protein from Macaca mulatta)
- Dh851.3 light chain (22 kDa, Protein from Macaca mulatta)
- Dh851.3 heavy chain (24 kDa, Protein from Macaca mulatta)
Cryo-EM map of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7lua
Q-score: 0.267
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Ch848 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Env polyprotein (16 kDa, Protein from Simian-Human immunodeficiency virus)
- Cryo-em structure of dh898.1 fab-dimer bound near the cd4 binding site of hiv-1 env ch848 sosip trimer. (Complex from Human immunodeficiency virus 1)
- Dh898.1 heavy chain (23 kDa, Protein from Homo sapiens)
- Dh898.1 light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7l02
Q-score: 0.341
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex)
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex from Severe acute respiratory syndrome-related coronavirus)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to two copies of domain-swapped antibody 2G12
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7l06
Q-score: 0.303
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex from Homo sapiens)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7l09
Q-score: 0.365
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex from Homo sapiens)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6um5
Q-score: 0.347
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270 uca3 fab bound to hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17 dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Dh270 uca3 fab light chain (22 kDa, Protein from Homo sapiens)
- Dh270 uca3 fab heavy chain (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6um6
Q-score: 0.318
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270.6 heavy chain (25 kDa, Protein from Homo sapiens)
- Complex of antibody dh270.6 with hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- Ch848 10.17dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17dt gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.6 light chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6um7
Q-score: 0.301
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.mu1 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Dh270.mu1 fab light chain (24 kDa, Protein from Homo sapiens)
- Complex of dh270.mu1 and ch848 10.17dt envelope (360 kDa, Complex from Human immunodeficiency virus 1)
Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6uda
Q-score: 0.325
LaBranche CC, Henderson R, Hsu A, Behrens S, Chen X, Zhou T, Wiehe K, Saunders KO, Alam SM, Bonsignori M, Borgnia MJ, Sattentau QJ, Eaton A, Greene K, Gao H, Liao HX, Williams WB, Peacock J, Tang H, Perez LG, Edwards RJ, Kepler TB, Korber BT, Kwong PD, Mascola JR, Acharya P, Haynes BF, Montefiori DC
PLoS Pathog (2019) 15 pp. e1008026-e1008026 [ DOI: doi:10.1371/journal.ppat.1008026 Pubmed: 31527908 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch505.n279k.g458y.sosip.664 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Ch235 uca heavy chain fab (26 kDa, Protein from Homo sapiens)
- Ch235 uca light chain fab (25 kDa, Protein from Homo sapiens)
- Complex of the ch235 unmutated common ancestor (uca) bound to man5-enriched ch505.n279k.g458y.sosip.664 (360 kDa, Complex from Human immunodeficiency virus 1)
- Ch505.n279k.g458y.sosip.664 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)