Structure of a human NHE3-CHP1 complex in the autoinhibited state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7x2u
Q-score: 0.567
Dong Y, Li H, Ilie A, Gao Y, Boucher A, Zhang XC, Orlowski J, Zhao Y
Sci Adv (2022) [ ]
- Sodium/hydrogen exchanger 3 (70 kDa, Protein from Homo sapiens)
- [(2~{r})-2-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{s},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] hexadecanoate (811 Da, Ligand)
- Calcineurin b homologous protein 1 (21 kDa, Protein from Homo sapiens)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Human nhe3-chp1 complex (Complex from Homo sapiens)
Structure of a human NHE1-CHP1 complex under pH 6.5
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7dsv
Q-score: 0.421
Dong Y, Gao Y, Ilie A, Kim D, Boucher A, Li B, Zhang XC, Orlowski J, Zhao Y
Nat Commun (2021) 12 pp. 3474-3474 [ DOI: doi:10.1038/s41467-021-23496-z Pubmed: 34108458 ]
- Calcineurin b homologous protein 1 (chp1) (Complex)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Human nhe1-chp1 complex under ph 6.5 (230 kDa, Complex from Homo sapiens)
- Calcineurin b homologous protein 1 (21 kDa, Protein from Homo sapiens)
- Sodium/hydrogen exchanger 1 (52 kDa, Protein from Homo sapiens)
- Sodium/protein exchanger 1 (nhe1) (182 kDa, Complex from Homo sapiens)
Structure of a human NHE1-CHP1 complex under pH 7.5
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dsw
Q-score: 0.526
Dong Y, Gao Y, Ilie A, Kim D, Boucher A, Li B, Zhang XC, Orlowski J, Zhao Y
Nat Commun (2021) 12 pp. 3474-3474 [ DOI: doi:10.1038/s41467-021-23496-z Pubmed: 34108458 ]
- Sodium/hydrogen exchanger 1 (46 kDa, Protein from Homo sapiens)
- Human nhe1-chp1 complex under ph 7.5 (230 kDa, Complex from Homo sapiens)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7dsx
Q-score: 0.456
Dong Y, Gao Y, Ilie A, Kim D, Boucher A, Li B, Zhang XC, Orlowski J, Zhao Y
Nat Commun (2021) 12 pp. 3474-3474 [ DOI: doi:10.1038/s41467-021-23496-z Pubmed: 34108458 ]
- Sodium/hydrogen exchanger 1 (57 kDa, Protein from Homo sapiens)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Calcineurin b homologous protein 1 (chp1) under ph 7.5 (Complex)
- Calcineurin b homologous protein 1 (21 kDa, Protein from Homo sapiens)
- Sodium/protein exchanger 1 (nhe1) under ph 7.5, bound by cariporide (182 kDa, Complex from Homo sapiens)
- N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide (283 Da, Ligand)
- Human nhe1-chp1 complex under ph 7.5, bound by cariporide (230 kDa, Complex from Homo sapiens)