Resolution: 3.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ec7
Q-score: 0.374
Lu J, Ge P, Sawaya MR, Hughes MP, Boyer DR, Cao Q, Abskharon R, Cascio D, Tayeb-Fligelman E, Eisenberg DS
J Biol Chem (2023) 300 pp. 105531-105531 [ Pubmed: 38072051 DOI: doi:10.1016/j.jbc.2023.105531 ]
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8du2
Q-score: 0.509
Lu J, Ge P, Sawaya MR, Hughes MP, Boyer DR, Cao Q, Abskharon R, Cascio D, Tayeb-Fligelman E, Eisenberg DS
J Biol Chem (2023) 300 pp. 105531-105531 [ Pubmed: 38072051 DOI: doi:10.1016/j.jbc.2023.105531 ]
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8duw
Q-score: 0.551
Lu J, Ge P, Sawaya MR, Hughes MP, Boyer DR, Cao Q, Abskharon R, Cascio D, Tayeb-Fligelman E, Eisenberg DS
J Biol Chem (2023) 300 pp. 105531-105531 [ Pubmed: 38072051 DOI: doi:10.1016/j.jbc.2023.105531 ]
CryoEM structure of the LCD of hnRNPA2 amyloid-like fibrils
Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS
Nat Commun (2020) 11 [ Pubmed: 32796831 DOI: 10.1038/s41467-020-17905-y ]
Image sets:
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
hnRNPA2 Low complexity domain (LCD) determined by cryoEM
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 6wqk
Q-score: 0.574
Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS
Nat Commun (2020) 11 pp. 4090-4090 [ Pubmed: 32796831 DOI: doi:10.1038/s41467-020-17905-y ]
Structure of recombinantly assembled E46K alpha-synuclein fibrils
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 6ufr
Q-score: 0.656
Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS
PNAS (2020) 117 pp. 3592-3602 [ DOI: doi:10.1073/pnas.1917914117 Pubmed: 32015135 ]
- Water (18 Da, Ligand)
- Recombinantly assembled e46k alpha-synuclein fibril (Cellular component from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS
Nat Struct Mol Biol (2018) 25 pp. 463-471 [ DOI: doi:10.1038/s41594-018-0064-2 Pubmed: 29786080 ]
- Crystal of nfgtfs phosphorylated on threonine. (Complex from Homo sapiens)
- Nfgtfs (751 Da, Protein from Homo sapiens)
- Water (18 Da, Ligand)
SWGMMGMLASQ segment from the low complexity domain of TDP-43, residues 333-343
Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS
Nat Struct Mol Biol (2018) 25 pp. 463-471 [ DOI: doi:10.1038/s41594-018-0064-2 Pubmed: 29786080 ]
- Tar dna-binding protein 43 (1 kDa, Protein from Homo sapiens)
- Crystal of swgmmgmlasq (Complex from Homo sapiens)
Resolution: 1.0 Å
EM Method: Electron Crystallography
Fitted PDBs: 5wkb
Q-score: 0.383
Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS
Nat Struct Mol Biol (2018) 25 pp. 463-471 [ DOI: doi:10.1038/s41594-018-0064-2 Pubmed: 29786080 ]
- Segment from tdp-43 (Cellular component from Homo sapiens)
- Water (18 Da, Ligand)
- Tar dna-binding protein 43 (699 Da, Protein from Homo sapiens)