Amyloid-Beta (20-34) with L-isoaspartate 23
Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG
Nat Commun (2019) 10 pp. 3357-3357 [ DOI: doi:10.1038/s41467-019-11183-z Pubmed: 31350392 ]
- Water (18 Da, Ligand)
- Amyloid-beta a4 protein (1 kDa, Protein from Homo sapiens)
- Crystal of amyloid-beta residues 20-34 with l-isoaspartate at position 23 (6 MDa, Complex)
Amyloid-Beta (20-34) wild type
Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG
Nat Commun (2019) 10 pp. 3357-3357 [ DOI: doi:10.1038/s41467-019-11183-z Pubmed: 31350392 ]
- Water (18 Da, Ligand)
- Crystal of amyloid-beta residues 20-34 wild type (6 MDa, Complex from Homo sapiens)
- Amyloid beta a4 protein (1 kDa, Protein from Homo sapiens)
CryoEM structure of the segment, DLIIKGISVHI, assembled into a triple-helical fibril
Resolution: 3.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 5w7v
Q-score: 0.498
Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS
Nat Struct Mol Biol (2018) 25 pp. 311-319 [ Pubmed: 29531287 DOI: doi:10.1038/s41594-018-0045-5 ]
- Tar dna-binding protein 43 (1 kDa, Protein from Homo sapiens)
- Dliikgisvhi fibril (Complex from Homo sapiens)
MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257
Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS
Nat Struct Mol Biol (2018) 25 pp. 311-319 [ Pubmed: 29531287 DOI: doi:10.1038/s41594-018-0045-5 ]
- Dliikgisvhi fibril (5 MDa, Complex from Homo sapiens)
- Tar dna-binding protein 43 (1 kDa, Protein from Homo sapiens)
KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2
Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS
Nat Chem (2018) 10 pp. 170-176 [ Pubmed: 29359764 DOI: doi:10.1038/nchem.2889 ]
- Kvqiinkkld tau peptide (Cellular component from Homo sapiens)
- Water (18 Da, Ligand)
- Microtubule-associated protein tau (1 kDa, Protein from Homo sapiens)
VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2
Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS
Nat Chem (2018) 10 pp. 170-176 [ Pubmed: 29359764 DOI: doi:10.1038/nchem.2889 ]
- Microtubule-associated protein tau (714 Da, Protein from Homo sapiens)
- Vqiink tau peptide (Cellular component from Homo sapiens)
Segment from bank vole prion protein 168-176 QYNNQNNFV
Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA
Nat Struct Mol Biol (2018) 25 pp. 131-134 [ DOI: doi:10.1038/s41594-017-0018-0 Pubmed: 29335561 ]
- Water (18 Da, Ligand)
- Major prion protein (1 kDa, Protein from Myodes glareolus)
- Bank vole prion 168-176 (4 kDa, Complex from Myodes glareolus)
MicroED structure of carbamazepine at 0.85 A resolution
Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA
Nat Struct Mol Biol (2018) 25 pp. 131-134 [ DOI: doi:10.1038/s41594-017-0018-0 Pubmed: 29335561 ]
- Carbamazepine (234 Da, Complex from unidentified)