Structure of SARS-CoV-2 (HP-GSAS-Mut7) spike in complex with TXG-0078 Fab -Conformation 1
Hurtado J, Rogers TF, Jaffe DB, Adams BA, Bangaru S, Garcia E, Capozzola T, Messmer T, Sharma P, Song G, Beutler N, He W, Dueker K, Musharrafieh R, Burbach S, Truong A, Stubbington MJT, Burton DR, Andrabi R, Ward AB, McDonnell WJ, Briney B
Cell Rep (2024) 43 pp. 114307-114307 [ Pubmed: 38848216 DOI: doi:10.1016/j.celrep.2024.114307 ]
Structure of SARS-CoV-2 (HP-GSAS-Mut7) spike in complex with TXG-0078 Fab -Conformation 2
Hurtado J, Rogers TF, Jaffe DB, Adams BA, Bangaru S, Garcia E, Capozzola T, Messmer T, Sharma P, Song G, Beutler N, He W, Dueker K, Musharrafieh R, Burbach S, Truong A, Stubbington MJT, Burton DR, Andrabi R, Ward AB, McDonnell WJ, Briney B
Cell Rep (2024) 43 pp. 114307-114307 [ Pubmed: 38848216 DOI: doi:10.1016/j.celrep.2024.114307 ]
Local refinement of SARS-CoV-2 (HP-GSAS-Mut7) spike NTD in complex with TXG-0078 Fab
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 8swh
Q-score: 0.326
Hurtado J, Rogers TF, Jaffe DB, Adams BA, Bangaru S, Garcia E, Capozzola T, Messmer T, Sharma P, Song G, Beutler N, He W, Dueker K, Musharrafieh R, Burbach S, Truong A, Stubbington MJT, Burton DR, Andrabi R, Ward AB, McDonnell WJ, Briney B
Cell Rep (2024) 43 pp. 114307-114307 [ Pubmed: 38848216 DOI: doi:10.1016/j.celrep.2024.114307 ]
- Txg-0078 fab heavy chain (16 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Structure of sars-cov-2(hp-gsas-mut7) spike in complex with txg-0078 fab- local refinement (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Txg-0078 fab light chain (14 kDa, Protein from Homo sapiens)
10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
Structure of lineage IV Lassa virus glycoprotein complex (strain Josiah)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ejd
Q-score: 0.373
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
Structure of lineage II Lassa virus glycoprotein complex (strain NIG08-A41)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8eje
Q-score: 0.391
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein gp1 (28 kDa, Protein from Lassa mammarenavirus)
Structure of lineage V Lassa virus glycoprotein complex (strain Soromba-R)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8ejf
Q-score: 0.355
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp1 (29 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein gp2 (44 kDa, Protein from Lassa mammarenavirus)
Structure of lineage VII Lassa virus glycoprotein complex (strain Togo/2016/7082)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8ejg
Q-score: 0.429
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein gp1 (22 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8ejh
Q-score: 0.406
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (425 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- 12.1f fab light chain (11 kDa, Protein from Homo sapiens)
- 12.1f fab heavy chain (13 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lassa virus glycoprotein complex (Josiah) bound to 19.7E Fab
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8eji
Q-score: 0.39
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (325 kDa, Complex from Lassa mammarenavirus)
- 19.7e fab heavy chain (13 kDa, Protein from Homo sapiens)
- 19.7e fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)