BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 6dfg
Q-score: 0.348
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mature bg18 fragment antigen binding heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 md39 sosip trimer in complex with mature bg18 fragment antigen binding (570 kDa, Complex)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- Bg18 fragment (Complex from Homo sapiens)
- Mature bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 6dfh
Q-score: 0.392
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ DOI: doi:10.1126/science.aax4380 Pubmed: 31672916 ]
- Sosip trimer (Complex from Human immunodeficiency virus 1)
- Bg505 md64 n332-gt2 sosip trimer in complex with germline-reverted bg18 fragment antigen binding (570 kDa, Complex)
- Bg18 fragment antigen (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- Germline-reverted bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Germline-reverted bg18 fragment antigen binding heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ DOI: doi:10.1126/science.aax4380 Pubmed: 31672916 ]
- Hmp42 fragment antigen binding (Complex from Homo sapiens)
- Rm20a3 fragment antigen binding heavy chain (Protein from Macaca mulatta)
- Bg18-like precursor hmp42 fragment antigen binding heavy chain (Protein from Homo sapiens)
- Bg505 md64 n332-gt5 sosip trimer in complex with bg18-like precursor hmp42 fragment antigen binding and base-binding rm20a3 fragment antigen binding (720 kDa, Complex)
- Rm20a3 fragment antigen binding light chain (Protein from Macaca mulatta)
- Bg18-like precursor hmp42 fragment antigen binding light chain (Protein from Homo sapiens)
- Bg505 md64 n332-gt5 sosip (Protein from Human immunodeficiency virus 1)
- Bg505 md64 n332-gt5 sosip trimer (Complex from Human immunodeficiency virus 1)
- Rm20a3 fragment antigen binding (Complex from Macaca mulatta)
Landais E, Murrell B, Briney B, Murrell S, Rantalainen K, Berndsen ZT, Ramos A, Wickramasinghe L, Smith ML, Eren K, de Val N, Wu M, Cappelletti A, Umotoy J, Lie Y, Wrin T, Algate P, Chan-Hui PY, Karita E, Ward AB, Wilson IA, Burton DR, Smith D, Pond SLK, Poignard P
Immunity (2017) 47 pp. 990-1003.e9 [ DOI: doi:10.1016/j.immuni.2017.11.002 Pubmed: 29166592 ]
- Hiv-1 envelope glycoprotein sosip.664 clone pc64m4c054 in complex with autologous fab pct64-13c (275 kDa, Complex from Human immunodeficiency virus 1)
- Immunoglobulin g pct64-13c light chain (Protein from Homo sapiens)
- Immunoglobulin g pct64-13c heavy chain (Protein from Homo sapiens)
- Hiv-1 envelope glycoprotein sosip.664 clone pc64m4c054 (Protein from Human immunodeficiency virus 1)