Structure of DNMT3A1-DNMt3L complex on a nucleosome
Wapenaar H, Clifford G, Rolls W, Burdett H, Zhang Y, Deák G, Zou J, Taylor MRD, Mills J, Watson JA, Kumar D, Das A, Valsakumar D, Bramham J, Voigt P, Wilson MD
bioRxiv (2023) [ DOI: 10.1101/2023.10.29.564595 ]
Image sets:
Structure of DNMT3A1 UDR region bound to H2AK119ub nucleosome
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8qzm
Q-score: 0.506
Wapenaar H, Clifford G, Rolls W, Pasquier M, Burdett H, Zhang Y, Deak G, Zou J, Spanos C, Taylor MRD, Mills J, Watson JA, Kumar D, Clark R, Das A, Valsakumar D, Bramham J, Voigt P, Sproul D, Wilson MD
EMBO Rep (2024) 25 pp. 5743-5779 [ Pubmed: 39528729 DOI: doi:10.1038/s44319-024-00306-3 ]
- Histone h2a type 1 (13 kDa, Protein from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Dnmt3a1-dnmt3l complex (Complex from Homo sapiens)
- Dna (145-mer) (60 kDa, DNA from synthetic construct)
- Dna (145-mer) (59 kDa, DNA from synthetic construct)
- Dna (cytosine-5)-methyltransferase 3a (102 kDa, Protein from Homo sapiens)
- Dnmt3a1-dnmt3l in complex with a human h2akc119ub nucleosome wrapped with 195bp of widom-601 positioning dna (147 kDa, Complex from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Ubiquitin (Complex from Homo sapiens)
- H2akc119ub nucleosome wrapped with 195 bp widom601 dna (Complex from Homo sapiens)
- Histone h3 (fragment) (15 kDa, Protein from Homo sapiens)
Cryo-EM density map of DNMT3A1-DNMT3L on a human H2AKc119ub nucleosome at 5.1 A resolution
Wapenaar H, Clifford G, Rolls W, Pasquier M, Burdett H, Zhang Y, Deak G, Zou J, Spanos C, Taylor MRD, Mills J, Watson JA, Kumar D, Clark R, Das A, Valsakumar D, Bramham J, Voigt P, Sproul D, Wilson MD
EMBO Rep (2024) 25 pp. 5743-5779 [ Pubmed: 39528729 DOI: doi:10.1038/s44319-024-00306-3 ]
- Dnmt3l (Protein from Homo sapiens)
- Ubiquitin (Protein from Homo sapiens)
- Dnmt3a1-dnmt3l complex (Complex from Homo sapiens)
- Dnmt3a1-dnmt3l in complex with a human h2akc119ub nucleosome wrapped with 195bp of widom-601 positioning dna (147 kDa, Complex from Homo sapiens)
- Histone h3 (Protein from Homo sapiens)
- H2akc119ub nucleosome wrapped with 195 bp widom601 dna (Complex from Homo sapiens)
- Histone h4 (Protein from Homo sapiens)
- 195bp widom601 dna (DNA from synthetic construct)
- Histone h2b (Protein from Homo sapiens)
- Dnmt3a1 (Protein from Homo sapiens)
- Histone h2ak119c (Protein from Homo sapiens)
Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ Pubmed: 37823591 DOI: 10.1093/nar/gkad793 ]
Image sets:
Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8off
Q-score: 0.516
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ DOI: doi:10.1093/nar/gkad793 Pubmed: 37823591 ]
- Dna (142-mer) (108 kDa, DNA from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (14 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Brca1 associated ring domain 1 (85 kDa, Protein from Felis catus)
- Brca1 associated ring domain 1 (Complex from Felis catus)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Bard1 ard-brcts in complex with h2akc15ub nucleosomes (246 kDa, Complex)
- Dna, histones and polyubiquitin-b (Complex from Homo sapiens)
Low-resolution structure of BRCA1dExon11-FL BARD1 (closed state)
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ DOI: doi:10.1093/nar/gkad793 Pubmed: 37823591 ]
- Heterodimeric complex of brca1dexon11 and fl bard1 (175 kDa, Complex from Felis catus)
Low-resolution structure of BRCA1dExon11-FL BARD1 (open state)
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ DOI: doi:10.1093/nar/gkad793 Pubmed: 37823591 ]
- Heterodimeric complex of brca1dexon11 and fl bard1 (175 kDa, Complex from Felis catus)
Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map 2)
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ DOI: doi:10.1093/nar/gkad793 Pubmed: 37823591 ]
Structure of the Nucleosome Core Particle from Trypanosoma brucei
Deák G, Wapenaar H, Sandoval G, Chen R, Taylor MRD, Burdett H, Watson JA, Tuijtel MW, Webb S, Wilson MD
Nucleic Acids Res (2023) [ DOI: 10.1093/nar/gkad577 Pubmed: 37427792 ]
Image sets:
Structure of the Nucleosome Core Particle from Trypanosoma brucei
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8com
Q-score: 0.439
Deak G, Wapenaar H, Sandoval G, Chen R, Taylor MRD, Burdett H, Watson JA, Tuijtel MW, Webb S, Wilson MD
Nucleic Acids Res (2023) 51 pp. 7882-7899 [ DOI: doi:10.1093/nar/gkad577 Pubmed: 37427792 ]
- Widom 601 145 bp dna (Complex from synthetic construct)
- Histone h2a (14 kDa, Protein from Trypanosoma brucei brucei TREU927)
- Nucleosome core particle (89 kDa, Complex from Trypanosoma brucei brucei TREU927)
- Histone h4 (11 kDa, Protein from Trypanosoma brucei brucei TREU927)
- Histone h3, putative (14 kDa, Protein from Trypanosoma brucei brucei TREU927)
- Widom 601 145 bp dna (127-mer ordered and built) (44 kDa, DNA from synthetic construct)
- Histone octamer (Complex from Trypanosoma brucei brucei TREU927)
- Widom 601 145 bp dna (127-mer ordered and built) (44 kDa, DNA from synthetic construct)
- Histone h2b (12 kDa, Protein from Trypanosoma brucei brucei TREU927)