Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae)
- Cell division cycle protein cdt1 (68 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 1 (108 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
- Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (111 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna (42-mer) (12 kDa, DNA from synthetic construct)
OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. Consensus map
Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. ORC local refinement.
Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. Composite map.
Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae)
- Cell division cycle protein cdt1 (68 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 1 (108 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
- Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (111 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna (42-mer) (12 kDa, DNA from synthetic construct)
OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 1
Nat Commun (2025) 16 pp. 782-782 [ Pubmed: 39824870 DOI: doi:10.1038/s41467-025-56143-y ]
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae)
- Cell division cycle protein cdt1 (68 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 2 (64 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 1 (108 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae)
- Dna (12 kDa, DNA from synthetic construct)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Orc-cdt1-mcm complex (1 MDa, Complex from Saccharomyces cerevisiae)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (111 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
X. laevis CMG dimer bound to dimeric DONSON - without ATPase
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8q6o
Q-score: 0.471
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017- [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication licensing factor mcm5-a (82 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf3 (23 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm6 (92 kDa, Protein from Xenopus laevis)
- X. laevis cmg dimer bound to dimeric donson (1 MDa, Complex from Xenopus laevis)
- Cell division control protein 45 homolog (65 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm7-b (81 kDa, Protein from Xenopus laevis)
- Protein downstream neighbor of son homolog (63 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf1 (23 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf2 (21 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm3 (90 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein sld5 (25 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm4-b (97 kDa, Protein from Xenopus laevis)