A neutralizing nanobody VHH60 against wt SARS-CoV-2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xki
Q-score: 0.441
Liu Q, Lu Y, Cai C, Huang Y, Zhou L, Guan Y, Fu S, Lin Y, Yan H, Zhang Z, Li X, Yang X, Yang H, Guo H, Lan K, Chen Y, Hou SC, Xiong Y
Cell Death Dis (2024) 15 pp. 458-458 [ Pubmed: 38937437 DOI: doi:10.1038/s41419-024-06802-7 ]
- Sars-cov-2 spike glycoprotein complex with vhh60 nanobody (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nanobody vhh60 (13 kDa, Protein from synthetic construct)
- Nanobody (Complex from synthetic construct)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xzg
Q-score: 0.495
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the [pyr1]-apelin-13-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of CB1-beta-arrestin1 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wu1
Q-score: 0.473
Liao YY, Zhang H, Shen Q, Cai C, Ding Y, Shen DD, Guo J, Qin J, Dong Y, Zhang Y, Li XM
Cell (2023) 186 pp. 5784-5797.e17 [ Pubmed: 38101408 DOI: doi:10.1016/j.cell.2023.11.017 ]
- Beta-arrestin-1 (44 kDa, Protein from Bos taurus)
- Fab30 heavy chain (25 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1,vasopressin v2 receptor (50 kDa, Protein from Homo sapiens)
- Cryo-em structure of human cannabinoid receptor 1 with effector protein (Complex from Bos taurus)
- Methyl n-{1-[(4-fluorophenyl)methyl]-1h-indazole-3-carbonyl}-3-methyl-l-valinate (397 Da, Ligand)
- Fab30 light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of the WN561-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzf
Q-score: 0.578
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Cryo-em structure of the wn561-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Wn561 (1 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the MM07-bound human APLNR-Gi complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xzh
Q-score: 0.649
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the mm07-bound human aplnr-gi complex (Complex from Homo sapiens)
- Mm07 (1 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8xzi
Q-score: 0.588
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (3~{s})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid (455 Da, Ligand)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the cmf-019-bound human aplnr-gi complex (Complex from Homo sapiens)
Cryo-EM structure of the WN353-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzj
Q-score: 0.509
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the wn353-bound human aplnr-gi complex (Complex from Homo sapiens)
- Wn353 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
The focused refinement map (Receptor) of the MM07 bound APLNR-Gi1 structure.
The focused refinement map (G-protein) of MM07 bound APLNR-Gi1 structure.
The low resolution consensus map of the MM07 bound APLNR-Gi1 structure.