Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ayl
Q-score: 0.511
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ Pubmed: 36966141 DOI: doi:10.1038/s41467-023-37259-5 ]
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one (443 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Resting state glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-61432059 (Complex from Rattus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8aym
Q-score: 0.472
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ Pubmed: 36966141 DOI: doi:10.1038/s41467-023-37259-5 ]
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-55511118 (Complex from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1h-benzimidazol-2-ol (328 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8ayn
Q-score: 0.558
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ Pubmed: 36966141 DOI: doi:10.1038/s41467-023-37259-5 ]
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- 6-[(1~{s})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{h}-1,3-benzothiazol-2-one (382 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand ly3130481 (Complex from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ayo
Q-score: 0.498
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ Pubmed: 36966141 DOI: doi:10.1038/s41467-023-37259-5 ]
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one (443 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-61432059 (Complex from Rattus norvegicus)
- Cyclothiazide (389 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7oca
Q-score: 0.525
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ Pubmed: 34079129 DOI: doi:10.1038/s41586-021-03613-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Protein cornichon homolog 2 (22 kDa, Protein from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Glua1/a2 heterotertramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (527 kDa, Complex from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
NTD of resting state GluA1/A2 heterotertramer
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7occ
Q-score: 0.511
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ Pubmed: 34079129 DOI: doi:10.1038/s41586-021-03613-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Glua1/a2 heterotertramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (Complex from Rattus norvegicus)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ocd
Q-score: 0.495
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ Pubmed: 34079129 DOI: doi:10.1038/s41586-021-03613-0 ]
- Glua1/a2 heterotetramer in complex with auxiliary subunit tarp gamma 8 (Complex from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7oce
Q-score: 0.541
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ Pubmed: 34079129 DOI: doi:10.1038/s41586-021-03613-0 ]
- Glua1/a2 heterotetramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (527 kDa, Complex from Rattus norvegicus)
- Glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Protein cornichon homolog 2 (22 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7ocf
Q-score: 0.465
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ Pubmed: 34079129 DOI: doi:10.1038/s41586-021-03613-0 ]
- Glua1/a2 heterotetramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (527 kDa, Complex from Rattus norvegicus)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Protein cornichon homolog 2 (22 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Cyclothiazide (389 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
GluA1/2 In complex with auxiliary subunit gamma-8
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6qkc
Q-score: 0.376
Herguedas B, Watson JF, Ho H, Cais O, Garcia-Nafria J, Greger IH
Science (2019) 364 [ DOI: doi:10.1126/science.aav9011 Pubmed: 30872532 ]
- Glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Glua1/a2 bound to gamma-8 (447 MDa, Complex from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)