Cryo-EM structure of human type I OSM receptor complex: model for full extracellular assembly
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 8v29
Q-score: 0.219
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human osm in complex with gp130 and lifr (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Oncostatin-m (22 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Cryo-EM structure of human type I OSM receptor complex: model for assembly core region
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8v2a
Q-score: 0.438
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human osm in complex with gp130 and lifr (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Oncostatin-m (22 kDa, Protein from Homo sapiens)
- Human osm (Complex from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Gp130 and lifr (Complex from Homo sapiens)
Cryo-EM structure of mouse type II OSM receptor complex: model for full extracellular assembly
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8v2b
Q-score: 0.31
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Oncostatin-m-specific receptor subunit beta (82 kDa, Protein from Mus musculus)
- Interleukin-6 receptor subunit beta (70 kDa, Protein from Mus musculus)
- Oncostatin-m (20 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse osm in complex with gp130 and osmr (Complex)
Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8v2c
Q-score: 0.479
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Oncostatin-m-specific receptor subunit beta (82 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse osm in complex with gp130 and osmr (Complex)
- Interleukin-6 receptor subunit beta (70 kDa, Protein from Mus musculus)
- Oncostatin-m (20 kDa, Protein from Mus musculus)
Cryo-EM map of human LIF signaling complex with full extracellular domains
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8d6a
Q-score: 0.357
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human lif in complex with gp130 and lifr (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor (19 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8d74
Q-score: 0.432
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Cryo-EM structure of human CNTFR alpha in complex with the Fab fragments of two antibodies
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8d7e
Q-score: 0.517
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Human cntfr alpha in complex with the fab fragments of two antibodies (Complex from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (39 kDa, Protein from Homo sapiens)
- H4h25311p2 antibody fab fragment heavy chain (23 kDa, Protein from Homo sapiens)
- H4h25311p2 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)
- Regn8938 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)
- Regn8938 antibody fab fragment heavy chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of human CLCF1 in complex with CRLF1 and CNTFR alpha
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8d7h
Q-score: 0.394
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (39 kDa, Protein from Homo sapiens)
- Cytokine receptor-like factor 1 (44 kDa, Protein from Homo sapiens)
- Human clcf1 in complex with in complex with crlf1 and cntfr alpha (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
Cryo-EM map of human CLCF1 signaling complex with full extracellular domains
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8d7r
Q-score: 0.268
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Human clcf1 in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (36 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Cryo-EM map of detergent-solubilized human IL-6 signaling complex with full extracellular domains
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8d82
Q-score: 0.392
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Interleukin-6 receptor subunit beta (77 kDa, Protein from Homo sapiens)
- Human il-6 in complex with il-6r alpha and detergent-solubilized gp130 (Complex from Homo sapiens)
- Soluble interleukin-6 receptor subunit alpha (38 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 (20 kDa, Protein from Homo sapiens)