Cryo-EM structure of human type I OSM receptor complex: model for full extracellular assembly
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 8v29
Q-score: 0.219
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human osm in complex with gp130 and lifr (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Oncostatin-m (22 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Cryo-EM structure of human type I OSM receptor complex: model for assembly core region
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8v2a
Q-score: 0.438
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human osm in complex with gp130 and lifr (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Oncostatin-m (22 kDa, Protein from Homo sapiens)
- Human osm (Complex from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Gp130 and lifr (Complex from Homo sapiens)
Cryo-EM structure of mouse type II OSM receptor complex: model for full extracellular assembly
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8v2b
Q-score: 0.31
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Oncostatin-m-specific receptor subunit beta (82 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse osm in complex with gp130 and osmr (Complex)
- Interleukin-6 receptor subunit beta (70 kDa, Protein from Mus musculus)
- Oncostatin-m (20 kDa, Protein from Mus musculus)
Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8v2c
Q-score: 0.479
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Oncostatin-m-specific receptor subunit beta (82 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse osm in complex with gp130 and osmr (Complex)
- Interleukin-6 receptor subunit beta (70 kDa, Protein from Mus musculus)
- Oncostatin-m (20 kDa, Protein from Mus musculus)
Cryo-EM map of human LIF signaling complex with full extracellular domains
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8d6a
Q-score: 0.357
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human lif in complex with gp130 and lifr (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor (19 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8d74
Q-score: 0.432
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Cryo-EM structure of human CNTFR alpha in complex with the Fab fragments of two antibodies
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8d7e
Q-score: 0.517
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Human cntfr alpha in complex with the fab fragments of two antibodies (Complex from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (39 kDa, Protein from Homo sapiens)
- H4h25311p2 antibody fab fragment heavy chain (23 kDa, Protein from Homo sapiens)
- H4h25311p2 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)
- Regn8938 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)
- Regn8938 antibody fab fragment heavy chain (23 kDa, Protein from Homo sapiens)
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Cryo-EM structure of human CLCF1 in complex with CRLF1 and CNTFR alpha
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8d7h
Q-score: 0.394
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (39 kDa, Protein from Homo sapiens)
- Cytokine receptor-like factor 1 (44 kDa, Protein from Homo sapiens)
- Human clcf1 in complex with in complex with crlf1 and cntfr alpha (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
Cryo-EM map of human CLCF1 signaling complex with full extracellular domains
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8d7r
Q-score: 0.268
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Human clcf1 in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (36 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)