Cryo-EM map of human LIF signaling complex with full extracellular domains
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8d6a
Q-score: 0.357
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human lif in complex with gp130 and lifr (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor (19 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8d74
Q-score: 0.432
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Cryo-EM structure of human CLCF1 in complex with CRLF1 and CNTFR alpha
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8d7h
Q-score: 0.394
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (39 kDa, Protein from Homo sapiens)
- Cytokine receptor-like factor 1 (44 kDa, Protein from Homo sapiens)
- Human clcf1 in complex with in complex with crlf1 and cntfr alpha (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
Cryo-EM map of human CLCF1 signaling complex with full extracellular domains
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8d7r
Q-score: 0.268
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Human clcf1 in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (36 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Cryo-EM map of detergent-solubilized human IL-6 signaling complex with full extracellular domains
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8d82
Q-score: 0.392
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Interleukin-6 receptor subunit beta (77 kDa, Protein from Homo sapiens)
- Human il-6 in complex with il-6r alpha and detergent-solubilized gp130 (Complex from Homo sapiens)
- Soluble interleukin-6 receptor subunit alpha (38 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 (20 kDa, Protein from Homo sapiens)
Cryo-EM map of human IL-27 signaling complex: focused refinement on the interaction core region
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8d85
Q-score: 0.336
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ DOI: doi:10.1126/sciadv.ade4395 Pubmed: 36930708 ]
- Human il-27 in complex with il-27r alpha and gp130 (Complex from Homo sapiens)
- Interleukin-27 subunit beta (23 kDa, Protein from Homo sapiens)
- Interleukin-27 subunit alpha (27 kDa, Protein from Homo sapiens)
- Interleukin-27 receptor subunit alpha (55 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of VTC complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ytj
Q-score: 0.485
Guan Z, Chen J, Liu R, Chen Y, Xing Q, Du Z, Cheng M, Hu J, Zhang W, Mei W, Wan B, Wang Q, Zhang J, Cheng P, Cai H, Cao J, Zhang D, Yan J, Yin P, Hothorn M, Liu Z
Nat Commun (2023) 14 pp. 718-718 [ Pubmed: 36759618 DOI: doi:10.1038/s41467-023-36466-4 ]
- Vacuolar transporter chaperone 3 (100 kDa, Protein from Saccharomyces cerevisiae)
- Vtc complex (Complex from Saccharomyces cerevisiae)
- Inositol hexakisphosphate (660 Da, Ligand)
- Vacuolar transporter chaperone 4 (86 kDa, Protein from Saccharomyces cerevisiae)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Vacuolar transporter chaperone 1 (15 kDa, Protein from Saccharomyces cerevisiae)
- Phosphate ion (94 Da, Ligand)
LH2-LH3 antenna in anti parallel configuration embedded in a nanodisc
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 7tuw
Q-score: 0.18
Wang D, Fiebig OC, Harris D, Toporik H, Ji Y, Chuang C, Nairat M, Tong AL, Ogren JI, Hart SM, Cao J, Sturgis JN, Mazor Y, Schlau-Cohen GS
PNAS (2023) 120 pp. e2220477120-e2220477120 [ Pubmed: 37399405 DOI: doi:10.1073/pnas.2220477120 ]
- Light-harvesting protein b-800/850 alpha chain (6 kDa, Protein from Magnetospirillum molischianum)
- Bacteriochlorophyll a (911 Da, Ligand)
- Lycopene (536 Da, Ligand)
- Light-harvesting protein b800-820 alpha chain (6 kDa, Protein from Magnetospirillum molischianum)
- Light-harvesting protein b-800/850 beta 1 chain (5 kDa, Protein from Magnetospirillum molischianum)
- Light-harvesting protein b800-820 beta chain (5 kDa, Protein from Magnetospirillum molischianum)
- Lh2 and lh3 antennae (Complex from Magnetospirillum molischianum)
LH2-LH3 antenna in parallel configuration embedded in a nanodisc
Resolution: 11.4 Å
EM Method: Single-particle
Fitted PDBs: 7tv3
Q-score: 0.084
Wang D, Fiebig OC, Harris D, Toporik H, Ji Y, Chuang C, Nairat M, Tong AL, Ogren JI, Hart SM, Cao J, Sturgis JN, Mazor Y, Schlau-Cohen GS
PNAS (2023) 120 pp. e2220477120-e2220477120 [ Pubmed: 37399405 DOI: doi:10.1073/pnas.2220477120 ]
- Light-harvesting protein b-800/850 alpha chain (6 kDa, Protein from Magnetospirillum molischianum)
- Bacteriochlorophyll a (911 Da, Ligand)
- Lycopene (536 Da, Ligand)
- Light-harvesting protein b800-820 alpha chain (6 kDa, Protein from Magnetospirillum molischianum)
- Light-harvesting protein b-800/850 beta 1 chain (4 kDa, Protein from Magnetospirillum molischianum)
- Light-harvesting protein b800-820 beta chain (5 kDa, Protein from Magnetospirillum molischianum)
- Lh2 and lh3 antennae (Complex from Magnetospirillum molischianum)
SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U)
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 7whb
Q-score: 0.479
Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2245921-2245921 [ DOI: doi:10.1080/22221751.2023.2245921 Pubmed: 37542391 ]
- Antibody zb8 light chain (23 kDa, Protein from Homo sapiens)
- Fab-spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody zb8 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab (Complex)