Cryo-EM map of detergent-solubilized human IL-6 signaling complex with full extracellular domains
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8d82
Q-score: 0.392
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Interleukin-6 receptor subunit beta (77 kDa, Protein from Homo sapiens)
- Human il-6 in complex with il-6r alpha and detergent-solubilized gp130 (Complex from Homo sapiens)
- Soluble interleukin-6 receptor subunit alpha (38 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 (20 kDa, Protein from Homo sapiens)
Cryo-EM map of human IL-27 signaling complex: focused refinement on the interaction core region
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8d85
Q-score: 0.336
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ DOI: doi:10.1126/sciadv.ade4395 Pubmed: 36930708 ]
- Human il-27 in complex with il-27r alpha and gp130 (Complex from Homo sapiens)
- Interleukin-27 subunit beta (23 kDa, Protein from Homo sapiens)
- Interleukin-27 subunit alpha (27 kDa, Protein from Homo sapiens)
- Interleukin-27 receptor subunit alpha (55 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of VTC complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ytj
Q-score: 0.485
Guan Z, Chen J, Liu R, Chen Y, Xing Q, Du Z, Cheng M, Hu J, Zhang W, Mei W, Wan B, Wang Q, Zhang J, Cheng P, Cai H, Cao J, Zhang D, Yan J, Yin P, Hothorn M, Liu Z
Nat Commun (2023) 14 pp. 718-718 [ Pubmed: 36759618 DOI: doi:10.1038/s41467-023-36466-4 ]
- Vacuolar transporter chaperone 3 (100 kDa, Protein from Saccharomyces cerevisiae)
- Vtc complex (Complex from Saccharomyces cerevisiae)
- Inositol hexakisphosphate (660 Da, Ligand)
- Vacuolar transporter chaperone 4 (86 kDa, Protein from Saccharomyces cerevisiae)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Vacuolar transporter chaperone 1 (15 kDa, Protein from Saccharomyces cerevisiae)
- Phosphate ion (94 Da, Ligand)
SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (focused refinement on Fab-RBD)
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7wh8
Q-score: 0.523
Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2245921-2245921 [ Pubmed: 37542391 DOI: doi:10.1080/22221751.2023.2245921 ]
- Spike glycoprotein (31 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody zb8 heavy chain (23 kDa, Protein from Homo sapiens)
- Fab-spike (Complex from Homo sapiens)
- Spike (Complex)
- Antibody zb8 light chain (23 kDa, Protein from Homo sapiens)
- Fab (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U)
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 7whb
Q-score: 0.479
Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2245921-2245921 [ DOI: doi:10.1080/22221751.2023.2245921 Pubmed: 37542391 ]
- Antibody zb8 light chain (23 kDa, Protein from Homo sapiens)
- Fab-spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody zb8 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab (Complex)
SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (2u1d)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 7whd
Q-score: 0.128
Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2245921-2245921 [ Pubmed: 37542391 DOI: doi:10.1080/22221751.2023.2245921 ]
- Spike (Complex from Homo sapiens)
- Antibody zb8 heavy chain (23 kDa, Protein from Homo sapiens)
- Fab-spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody zb8 light chain (23 kDa, Protein from Homo sapiens)
- Fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7w8s
Q-score: 0.582
Su C, He J, Han P, Bai B, Li D, Cao J, Tian M, Hu Y, Zheng A, Niu S, Chen Q, Rong X, Zhang Y, Li W, Qi J, Zhao X, Yang M, Wang Q, Gao GF
J Virol (2022) 96 pp. e0081422-e0081422 [ Pubmed: 36000849 DOI: doi:10.1128/jvi.00814-22 ]
- Cryo-em structure of sars-cov-2 rbd y453f complexed with american mink ace2 (Complex from Homo sapiens)
- Sars-cov-2 rbd (Complex)
- Angiotensin-converting enzyme 2 (70 kDa, Protein from Homo sapiens)
- American mink ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7wa1
Q-score: 0.551
Su C, He J, Han P, Bai B, Li D, Cao J, Tian M, Hu Y, Zheng A, Niu S, Chen Q, Rong X, Zhang Y, Li W, Qi J, Zhao X, Yang M, Wang Q, Gao GF
J Virol (2022) 96 pp. e0081422-e0081422 [ DOI: doi:10.1128/jvi.00814-22 Pubmed: 36000849 ]
- Zinc ion (65 Da, Ligand)
- Cryo-em structure of sars-cov-2 rbd f486l complexed with american mink ace2 (Complex from Homo sapiens)
- Angiotensin-converting enzyme 2 (70 kDa, Protein from Homo sapiens)
- Sars-cov-2 rbd (Complex)
- American mink ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the yeast mitochondrial SAM-Tom40 complex at 3.0 angstrom
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 7e4h
Q-score: 0.445
Wang Q, Guan Z, Qi L, Zhuang J, Wang C, Hong S, Yan L, Wu Y, Cao X, Cao J, Yan J, Zou T, Liu Z, Zhang D, Yan C, Yin P
Science (2021) 373 pp. 1377-1381 [ DOI: doi:10.1126/science.abh0704 Pubmed: 34446444 ]
- Sorting assembly machinery 37 kda subunit (40 kDa, Protein from Saccharomyces cerevisiae S288c)
- Sorting assembly machinery 35 kda subunit (37 kDa, Protein from Saccharomyces cerevisiae S288c)
- Sorting assembly machinery subunits (Complex from Saccharomyces cerevisiae S288c)
- Sorting assembly machinery 50 kda subunit (54 kDa, Protein from Saccharomyces cerevisiae S288c)
- Mitochondrial import receptor subunit tom40 (46 kDa, Protein from Saccharomyces cerevisiae S288c)
- Sam-tom40 complex (Complex from Saccharomyces cerevisiae S288c)
- Mitochondrial import receptor subunit tom40 (Complex)
Cryo-EM structure of the yeast mitochondrial SAM-Tom40/Tom5/Tom6 complex at 3.0 angstrom
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7e4i
Q-score: 0.485
Wang Q, Guan Z, Qi L, Zhuang J, Wang C, Hong S, Yan L, Wu Y, Cao X, Cao J, Yan J, Zou T, Liu Z, Zhang D, Yan C, Yin P
Science (2021) 373 pp. 1377-1381 [ DOI: doi:10.1126/science.abh0704 Pubmed: 34446444 ]
- Sam-tom40/tom5/tom6 complex (Complex from Saccharomyces cerevisiae S288c)
- Sorting assembly machinery 37 kda subunit (40 kDa, Protein from Saccharomyces cerevisiae S288c)
- Mitochondrial import receptor subunit tom6 (6 kDa, Protein from Saccharomyces cerevisiae S288c)
- Mitochondrial import receptor subunit tom5 (6 kDa, Protein from Saccharomyces cerevisiae S288c)
- Sorting assembly machinery 35 kda subunit (37 kDa, Protein from Saccharomyces cerevisiae S288c)
- Sorting assembly machinery subunits (Complex from Saccharomyces cerevisiae S288c)
- Sorting assembly machinery 50 kda subunit (54 kDa, Protein from Saccharomyces cerevisiae S288c)
- Mitochondrial import receptor subunits (Complex)
- Mitochondrial import receptor subunit tom40 (43 kDa, Protein from Saccharomyces cerevisiae S288c)