Cryo-EM structure of PDF-2180 Spike glycoprotein
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7u6r
Q-score: 0.63
Xiong Q, Cao L, Ma C, Tortorici MA, Liu C, Si J, Liu P, Gu M, Walls AC, Wang C, Shi L, Tong F, Huang M, Li J, Zhao C, Shen C, Chen Y, Zhao H, Lan K, Corti D, Veesler D, Wang X, Yan H
Nature (2022) 612 pp. 748-757 [ DOI: doi:10.1038/s41586-022-05513-3 Pubmed: 36477529 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Predict/pdf-2180 (Virus from PREDICT/PDF-2180)
- Pdf-2180 spike glycoprotein (147 kDa, Protein from Bat coronavirus)
Structure of NeoCOV RBD binding to Bat37 ACE2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wpo
Q-score: 0.458
Xiong Q, Cao L, Ma C, Tortorici MA, Liu C, Si J, Liu P, Gu M, Walls AC, Wang C, Shi L, Tong F, Huang M, Li J, Zhao C, Shen C, Chen Y, Zhao H, Lan K, Corti D, Veesler D, Wang X, Yan H
Nature (2022) 612 pp. 748-757 [ DOI: doi:10.1038/s41586-022-05513-3 Pubmed: 36477529 ]
- Angiotensin-converting enzyme (80 kDa, Protein from Pipistrellus pipistrellus)
- Neocov rbd-bat37 ace2 complex (Complex from Coronavirus Neoromicia/PML-PHE1/RSA/2011)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (21 kDa, Protein from Coronavirus Neoromicia/PML-PHE1/RSA/2011)
Structure of PDF-2180-COV RBD binding to Bat37 ACE2
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7wpz
Q-score: 0.427
Xiong Q, Cao L, Ma C, Tortorici MA, Liu C, Si J, Liu P, Gu M, Walls AC, Wang C, Shi L, Tong F, Huang M, Li J, Zhao C, Shen C, Chen Y, Zhao H, Lan K, Corti D, Veesler D, Wang X, Yan H
Nature (2022) 612 pp. 748-757 [ DOI: doi:10.1038/s41586-022-05513-3 Pubmed: 36477529 ]
- Pdf-2180-cov rbd-bat37 ace2 complex (Complex from Bat coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme (69 kDa, Protein from Pipistrellus pipistrellus)
- Spike glycoprotein (22 kDa, Protein from Bat coronavirus)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7wg7
Q-score: 0.338
Delta Spike Trimer(3 RBD Down)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wg8
Q-score: 0.374
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wg9
Q-score: 0.389
Neutral Omicron Spike Trimer in complex with ACE2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wgb
Q-score: 0.341
Cui Z, Liu P, Wang N, Wang L, Fan K, Zhu Q, Wang K, Chen R, Feng R, Jia Z, Yang M, Xu G, Zhu B, Fu W, Chu T, Feng L, Wang Y, Pei X, Yang P, Xie XS, Cao L, Cao Y, Wang X
Cell (2022) 185 pp. 860-871.e13 [ DOI: doi:10.1016/j.cell.2022.01.019 Pubmed: 35120603 ]
- Neutral omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (68 kDa, Protein from Homo sapiens)
Neutral Omicron Spike Trimer in complex with ACE2
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7wgc
Q-score: 0.373
Cui Z, Liu P, Wang N, Wang L, Fan K, Zhu Q, Wang K, Chen R, Feng R, Jia Z, Yang M, Xu G, Zhu B, Fu W, Chu T, Feng L, Wang Y, Pei X, Yang P, Xie XS, Cao L, Cao Y, Wang X
Cell (2022) 185 pp. 860-871.e13 [ DOI: doi:10.1016/j.cell.2022.01.019 Pubmed: 35120603 ]
- Neutral omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (68 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with Multivalent miniprotein inhibitor FUS231-P24 (2RBDs open)
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Multivalent miniprotein inhibitor fus231-p24 (Protein from Synthetic construct)
- Sars-cov-2 hexapro spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus231-p24 (Complex from Synthetic construct)
- Sars-cov-2 spike in complex with multivalent minibinder fus231-p24 (2rbds open) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hexapro spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS231-P24 (3RBDs open)
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ Pubmed: 35412328 DOI: doi:10.1126/scitranslmed.abn1252 ]
- Sars-cov-2 hexapro spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus231-p24 (Protein from Synthetic construct)
- Sars-cov-2 hexapro spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus231-p24 (Complex from Synthetic construct)
- Sars-cov-2 spike in complex with multivalent miniprotein inhibitor fus231-p24 (3rbds open) (Complex from Severe acute respiratory syndrome coronavirus 2)