Structure of the human two pore domain potassium ion channel TASK-3 (K2P9.1)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 9g9v
Q-score: 0.496
Hall PR, Jouen-Tachoire T, Schewe M, Proks P, Baukrowitz T, Carpenter EP, Newstead S, Rodstrom KEJ, Tucker SJ
Structure (2025) 33 pp. 115- [ DOI: doi:10.1016/j.str.2024.11.005 Pubmed: 39637865 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- K2p9.1 homodimer (610 kDa, Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Potassium channel subfamily k member 9 (30 kDa, Protein from Homo sapiens)
Structure of the human two pore domain potassium ion channel TASK-3 (K2P9.1) G236R mutant
Resolution: 2.48 Å
EM Method: Single-particle
Fitted PDBs: 9g9w
Q-score: 0.602
Hall PR, Jouen-Tachoire T, Schewe M, Proks P, Baukrowitz T, Carpenter EP, Newstead S, Rodstrom KEJ, Tucker SJ
Structure (2025) 33 pp. 115- [ DOI: doi:10.1016/j.str.2024.11.005 Pubmed: 39637865 ]
- K2p9.1 g236r homodimer (620 kDa, Complex from Homo sapiens)
- Potassium channel subfamily k member 9 (30 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 9g9x
Q-score: 0.506
Hall PR, Jouen-Tachoire T, Schewe M, Proks P, Baukrowitz T, Carpenter EP, Newstead S, Rodstrom KEJ, Tucker SJ
Structure (2025) 33 pp. 115- [ DOI: doi:10.1016/j.str.2024.11.005 Pubmed: 39637865 ]
- Potassium channel subfamily k member 3 (30 kDa, Protein from Homo sapiens)
- K2p3.1 homodimer (600 kDa, Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Structure of human ceramide synthase 6 (CerS6) bound to C16:0
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8qz6
Q-score: 0.48
Pascoa TC, Pike ACW, Tautermann CS, Chi G, Traub M, Quigley A, Chalk R, Stefanic S, Thamm S, Pautsch A, Carpenter EP, Schnapp G, Sauer DB
Nat Struct Mol Biol (2024) [ Pubmed: 39528795 DOI: doi:10.1038/s41594-024-01414-3 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nanobody-22 (15 kDa, Protein from Vicugna pacos)
- Isoform 2 of ceramide synthase 6 (42 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cers6-nb22 complex (114 kDa, Complex from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8qz7
Q-score: 0.518
Pascoa TC, Pike ACW, Tautermann CS, Chi G, Traub M, Quigley A, Chalk R, Stefanic S, Thamm S, Pautsch A, Carpenter EP, Schnapp G, Sauer DB
Nat Struct Mol Biol (2024) [ Pubmed: 39528795 DOI: doi:10.1038/s41594-024-01414-3 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nanobody-22 (15 kDa, Protein from Vicugna pacos)
- Isoform 2 of ceramide synthase 6 (42 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cers6-nb22 complex (114 kDa, Complex from Homo sapiens)
- (2~{r})-2-[2-[(5~{r},6~{r},7~{s},9~{s},11~{r},16~{r},18~{s},19~{s})-6-[(3~{r})-3-carboxy-5-oxidanyl-5-oxidanylidene-pentanoyl]oxy-19-(hexadecanoylamino)-5,9-dimethyl-11,16,18-tris(oxidanyl)icosan-7-yl]oxy-2-oxidanylidene-ethyl]butanedioic acid (960 Da, Ligand)
Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 9eot
Q-score: 0.487
Pascoa TC, Pike ACW, Tautermann CS, Chi G, Traub M, Quigley A, Chalk R, Stefanic S, Thamm S, Pautsch A, Carpenter EP, Schnapp G, Sauer DB
Nat Struct Mol Biol (2024) [ Pubmed: 39528795 DOI: doi:10.1038/s41594-024-01414-3 ]
- Cers6-nb02 complex (114 kDa, Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nanobody-02 (14 kDa, Protein from Vicugna pacos)
- Isoform 2 of ceramide synthase 6 (42 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
Structure of human SIT1 (focussed map / refinement)
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 8p2w
Q-score: 0.408
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
Structure of human SIT1:ACE2 complex (open PD conformation)
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8p2x
Q-score: 0.361
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-alpha-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Structure of human SIT1:ACE2 complex (closed PD conformation)
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8p2y
Q-score: 0.368
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-alpha-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Structure of human SIT1 bound to L-pipecolate (focussed map / refinement)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8p2z
Q-score: 0.481
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Chloride ion (35 Da, Ligand)
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- (2s)-piperidine-2-carboxylic acid (129 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)