Structure of human ceramide synthase 6 (CerS6) bound to C16:0
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8qz6
Q-score: 0.48
Pascoa TC, Pike ACW, Tautermann CS, Chi G, Traub M, Quigley A, Chalk R, Stefanic S, Thamm S, Pautsch A, Carpenter EP, Schnapp G, Sauer DB
Nat Struct Mol Biol (2024) [ Pubmed: 39528795 DOI: doi:10.1038/s41594-024-01414-3 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nanobody-22 (15 kDa, Protein from Vicugna pacos)
- Isoform 2 of ceramide synthase 6 (42 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cers6-nb22 complex (114 kDa, Complex from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8qz7
Q-score: 0.518
Pascoa TC, Pike ACW, Tautermann CS, Chi G, Traub M, Quigley A, Chalk R, Stefanic S, Thamm S, Pautsch A, Carpenter EP, Schnapp G, Sauer DB
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01414-3 Pubmed: 39528795 ]
- Isoform 2 of ceramide synthase 6 (42 kDa, Protein from Homo sapiens)
- Nanobody-22 (15 kDa, Protein from Vicugna pacos)
- (2~{r})-2-[2-[(5~{r},6~{r},7~{s},9~{s},11~{r},16~{r},18~{s},19~{s})-6-[(3~{r})-3-carboxy-5-oxidanyl-5-oxidanylidene-pentanoyl]oxy-19-(hexadecanoylamino)-5,9-dimethyl-11,16,18-tris(oxidanyl)icosan-7-yl]oxy-2-oxidanylidene-ethyl]butanedioic acid (960 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cers6-nb22 complex (114 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 9eot
Q-score: 0.487
Pascoa TC, Pike ACW, Tautermann CS, Chi G, Traub M, Quigley A, Chalk R, Stefanic S, Thamm S, Pautsch A, Carpenter EP, Schnapp G, Sauer DB
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01414-3 Pubmed: 39528795 ]
- Nanobody-02 (14 kDa, Protein from Vicugna pacos)
- Isoform 2 of ceramide synthase 6 (42 kDa, Protein from Homo sapiens)
- Cers6-nb02 complex (114 kDa, Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7nsg
Q-score: 0.539
Baronina A, Pike ACW, Yu X, Dong YY, Shintre CA, Tessitore A, Chu A, Rotty B, Venkaya S, Mukhopadhyay SMM, Borkowska O, Chalk R, Shrestha L, Burgess-Brown NA, Edwards AM, Arrowsmith CH, Bountra C, Han S, Carpenter EP
To Be Published
- Ternary complex of excitatory amino acid transporter 3 with inhibitor hip-b (160 kDa, Complex from Homo sapiens)
- Excitatory amino acid transporter 3 (53 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- (+)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
- (-)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
Cryo-EM structure of human TMEM45A
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7oqz
Q-score: 0.42
Grieben M, Pike ACW, Evans A, Shrestha L, Venkaya S, Mukhopadhyay SMM, Moreira T, Marsden BD, Burgess-Brown NA, Carpenter EP
To Be Published
- Transmembrane protein 45a (32 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Transmembrane protein 45a (Cellular component from Homo sapiens)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 6r7x
Q-score: 0.516
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Undecyl-maltoside (496 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7y
Q-score: 0.417
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Calcium ion (40 Da, Ligand)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
Resolution: 5.14 Å
EM Method: Single-particle
Fitted PDBs: 6r7z
Q-score: 0.269
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)