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primary_citation_author:"Carpenter EP" AND author_name:"Schofield CJ"
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2
Release date: June 22, 2022
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 7or0
Q-score: 0.576
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 7or0
Q-score: 0.576
Grieben M, Saward BG, Pike ACW, Schofield CJ, Carpenter EP
To Be Published
Sample:
- Transient receptor potential cation channel subfamily a member 1 (Cellular component from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Water (18 Da, Ligand)
- Transient receptor potential cation channel subfamily a member 1 (128 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}-[4-[4-[(azanylidene-$l^{4}-azanylidene)amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide (438 Da, Ligand)
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1
Release date: June 22, 2022
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 7or1
Q-score: 0.577
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 7or1
Q-score: 0.577
Grieben M, Saward BG, Pike ACW, Schofield CJ, Carpenter EP
To Be Published
Sample:
- Transient receptor potential cation channel subfamily a member 1 (Cellular component from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Water (18 Da, Ligand)
- Transient receptor potential cation channel subfamily a member 1 (128 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}-[4-[4-[(azanylidene-$l^{4}-azanylidene)amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide (438 Da, Ligand)