Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7nsg
Q-score: 0.539
Baronina A, Pike ACW, Yu X, Dong YY, Shintre CA, Tessitore A, Chu A, Rotty B, Venkaya S, Mukhopadhyay SMM, Borkowska O, Chalk R, Shrestha L, Burgess-Brown NA, Edwards AM, Arrowsmith CH, Bountra C, Han S, Carpenter EP
To Be Published
- Ternary complex of excitatory amino acid transporter 3 with inhibitor hip-b (160 kDa, Complex from Homo sapiens)
- Excitatory amino acid transporter 3 (53 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- (+)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
- (-)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6gyn
Q-score: 0.479
Shintre CA, Pike ACW, Tessitore A, Young M, Bushell SR, Strain-Damerell C, Mukhopadhyay S, Burgess-Brown NA, Huiskonen JT, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP
To Be Published
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (60 kDa, Protein from Homo sapiens)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (Cellular component from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6gyo
Q-score: 0.502
Shintre CA, Pike ACW, Tessitore A, Young M, Bushell SR, Strain-Damerell C, Mukhopadhyay S, Burgess-Brown NA, Huiskonen JT, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP
To Be Published
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (60 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphoinositol (836 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Adenosine-3',5'-cyclic-monophosphate (329 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Unknown atom or ion (65 Da, Ligand)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (Cellular component from Homo sapiens)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 6r7x
Q-score: 0.516
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Undecyl-maltoside (496 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7y
Q-score: 0.417
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Calcium ion (40 Da, Ligand)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
Resolution: 5.14 Å
EM Method: Single-particle
Fitted PDBs: 6r7z
Q-score: 0.269
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
CryoEM structure of a human TRP channel
Resolution: 4.22 Å
EM Method: Single-particle
Fitted PDBs: 5k47
Q-score: 0.331
Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP
Nat Struct Mol Biol (2017) 24 pp. 114-122 [ Pubmed: 27991905 DOI: doi:10.1038/nsmb.3343 ]
- Polycystin-2 channel tetramer (residues 185-723) (256 kDa, Cellular component from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Polycystin-2 (63 kDa, Protein from Homo sapiens)