Structure of the human two pore domain potassium ion channel TASK-3 (K2P9.1) G236R mutant
Resolution: 2.48 Å
EM Method: Single-particle
Fitted PDBs: 9g9w
Q-score: 0.602
Hall PR, Jouen-Tachoire T, Schewe M, Proks P, Baukrowitz T, Carpenter EP, Newstead S, Rodstrom KEJ, Tucker SJ
Structure (2025) 33 pp. 115- [ DOI: doi:10.1016/j.str.2024.11.005 Pubmed: 39637865 ]
- K2p9.1 g236r homodimer (620 kDa, Complex from Homo sapiens)
- Potassium channel subfamily k member 9 (30 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 7or0
Q-score: 0.576
Grieben M, Saward BG, Pike ACW, Schofield CJ, Carpenter EP
To Be Published
- Transient receptor potential cation channel subfamily a member 1 (Cellular component from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Water (18 Da, Ligand)
- Transient receptor potential cation channel subfamily a member 1 (128 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}-[4-[4-[(azanylidene-$l^{4}-azanylidene)amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide (438 Da, Ligand)
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 7or1
Q-score: 0.577
Grieben M, Saward BG, Pike ACW, Schofield CJ, Carpenter EP
To Be Published
- Transient receptor potential cation channel subfamily a member 1 (Cellular component from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Water (18 Da, Ligand)
- Transient receptor potential cation channel subfamily a member 1 (128 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}-[4-[4-[(azanylidene-$l^{4}-azanylidene)amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide (438 Da, Ligand)
CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(4,5)P2
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 6t9n
Q-score: 0.576
Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP
Structure (2020) 28 pp. 169-184.e5 [ DOI: doi:10.1016/j.str.2019.11.005 Pubmed: 31806353 ]
- Cholesterol (386 Da, Ligand)
- Polycystin-2 channel tetramer (256 kDa, Cellular component from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Undecyl-maltoside (496 Da, Ligand)
- Polycystin-2 (63 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)