CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7y
Q-score: 0.417
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Calcium ion (40 Da, Ligand)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
cryoEM Structure of Polycystin-2 in complex with cations and lipids
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5mke
Q-score: 0.303
Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kuhlbrandt W, Witzgall R, Ziegler C
Nat Struct Mol Biol (2017) 24 pp. 123-130 [ Pubmed: 28092368 DOI: doi:10.1038/nsmb.3357 ]
- Polycystin-2 (109 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-dipalmitoyl-sn-glycero-3-phosphate (647 Da, Ligand)
- 4-amino-5-cyclohexyl-3-hydroxy-pentanoic acid (215 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Polycystin-2 (Complex from homo sapiens)
cryoEM Structure of Polycystin-2 in complex with calcium and lipids
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 5mkf
Q-score: 0.369
Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kuhlbrandt W, Witzgall R, Ziegler C
Nat Struct Mol Biol (2017) 24 pp. 123-130 [ Pubmed: 28092368 DOI: doi:10.1038/nsmb.3357 ]
- 4-amino-5-cyclohexyl-3-hydroxy-pentanoic acid (215 Da, Ligand)
- 1,2-dipalmitoyl-sn-glycero-3-phosphate (647 Da, Ligand)
- Polycystin-2 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Polycystin-2 (109 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
CryoEM structure of a human TRP channel
Resolution: 4.22 Å
EM Method: Single-particle
Fitted PDBs: 5k47
Q-score: 0.331
Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP
Nat Struct Mol Biol (2017) 24 pp. 114-122 [ Pubmed: 27991905 DOI: doi:10.1038/nsmb.3343 ]
- Polycystin-2 channel tetramer (residues 185-723) (256 kDa, Cellular component from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Polycystin-2 (63 kDa, Protein from Homo sapiens)