T33-ml28 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8ui2
Q-score: 0.594
Meador K, Castells-Graells R, Aguirre R, Sawaya MR, Arbing MA, Sherman T, Senarathne C, Yeates TO
Structure (2024) 32 pp. 751-765.e11 [ DOI: doi:10.1016/j.str.2024.02.017 Pubmed: 38513658 ]
- T33-ml28-redesigned-cuta-fold (11 kDa, Protein from synthetic construct)
- T33-ml28-redesigned-tandem-bmc-t-fold (21 kDa, Protein from synthetic construct)
- T33-ml28 designed tetrahedral protein cage using machine learning (400 kDa, Complex from synthetic construct)
T33-ml23 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
Resolution: 2.02 Å
EM Method: Single-particle
Fitted PDBs: 8uf0
Q-score: 0.687
Meador K, Castells-Graells R, Aguirre R, Sawaya MR, Arbing MA, Sherman T, Senarathne C, Yeates TO
Structure (2024) 32 pp. 751-765.e11 [ DOI: doi:10.1016/j.str.2024.02.017 Pubmed: 38513658 ]
- Water (18 Da, Ligand)
- T33-ml23-redesigned-tandem-bmc-t-fold (21 kDa, Protein from synthetic construct)
- T33-ml23-redesigned-cuta-fold (11 kDa, Protein from synthetic construct)
- T33-ml23 designed tetrahedral protein cage using machine learning (400 kDa, Complex from synthetic construct)
T33-ml35 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8ump
Q-score: 0.586
Meador K, Castells-Graells R, Aguirre R, Sawaya MR, Arbing MA, Sherman T, Senarathne C, Yeates TO
Structure (2024) 32 pp. 751-765.e11 [ DOI: doi:10.1016/j.str.2024.02.017 Pubmed: 38513658 ]
- T33-ml35-redesigned-tpr-domain-fold (13 kDa, Protein from synthetic construct)
- T33-ml35 designed tetrahedral protein cage using machine learning (400 kDa, Complex from synthetic construct)
- T33-ml35-redesigned-cuta-fold (14 kDa, Protein from synthetic construct)
Cryo-EM imaging scaffold subunits A and B used to display KRAS G12C complex with GDP
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8g3k
Q-score: 0.668
Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JE, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, Yeates TO
PNAS (2023) 120 pp. e2305494120-e2305494120 [ DOI: doi:10.1073/pnas.2305494120 Pubmed: 37669364 ]
Green Fluorescence Protein imaged on a cryo-EM imaging scaffold
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8g4e
Q-score: 0.566
Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JE, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, Yeates TO
PNAS (2023) 120 pp. e2305494120-e2305494120 [ DOI: doi:10.1073/pnas.2305494120 Pubmed: 37669364 ]
KRAS G12V complex with GDP imaged on a cryo-EM imaging scaffold
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8g4f
Q-score: 0.546
Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JE, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, Yeates TO
PNAS (2023) 120 pp. e2305494120-e2305494120 [ DOI: doi:10.1073/pnas.2305494120 Pubmed: 37669364 ]
- Kras g12v complex with gdp displayed on a cryo-em imaging scaffold (Complex from synthetic construct)
- Gtpase kras (19 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Rcg-33 - cryo-em imaging scaffold subunit b fused to darpin (35 kDa, Protein from synthetic construct)
KRAS G13C complex with GDP imaged on a cryo-EM imaging scaffold
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8g4h
Q-score: 0.548
Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JE, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, Yeates TO
PNAS (2023) 120 pp. e2305494120-e2305494120 [ DOI: doi:10.1073/pnas.2305494120 Pubmed: 37669364 ]
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Gtpase kras (19 kDa, Protein from Homo sapiens)
- Rcg-33 - cryo-em imaging scaffold subunit b fused to darpin (35 kDa, Protein from synthetic construct)
- Kras g13c complex with gdp displayed on a cryo-em imaging scaffold (Complex from synthetic construct)