Rat Cardiac Sodium Channel with Ranolazine Bound
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8f6p
Q-score: 0.512
Lenaeus M, Gamal El-Din TM, Tonggu L, Zheng N, Catterall WA
Nat Cardiovasc Res (2023) 2 pp. 587-594 [ Pubmed: 39185478 DOI: doi:10.1038/s44161-023-00271-5 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Complex of rat cardiac sodium channel with the antiarrhythmic drug ranolazine (250 kDa, Complex from Rattus norvegicus)
- (r)-ranolazine (427 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Cardiac Sodium channel with toxin bound
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7k18
Q-score: 0.411
Jiang D, Tonggu L, Gamal El-Din TM, Banh R, Pomes R, Zheng N, Catterall WA
Nat Commun (2021) 12 pp. 128-128 [ Pubmed: 33397917 DOI: doi:10.1038/s41467-020-20078-3 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha, enhanced green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Sodium channel protein type 5 subunit alpha (Complex from Rattus norvegicus)
- Cryo-em map for sodium channel and scorpion toxin complex (250 kDa, Complex)
- Alpha-like toxin lqh3 (Complex from Leiurus hebraeus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Alpha-like toxin lqh3 (7 kDa, Protein from Leiurus hebraeus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7k48
Q-score: 0.34
Wisedchaisri G, Tonggu L, Gamal El-Din TM, McCord E, Zheng N, Catterall WA
Mol Cell (2021) 81 pp. 38-48.e4 [ Pubmed: 33232657 DOI: doi:10.1016/j.molcel.2020.10.039 ]
- M3-huwentoxin-iv (Complex from Haplopelma schmidti)
- Mu-theraphotoxin-hs2a (3 kDa, Protein from Haplopelma schmidti)
- Complex of navab/nav1.7-vs2a chimera and m3-huwentoxin-iv (300 kDa, Complex)
- Navab/nav1.7-vs2a chimera (Complex from Escherichia coli)
- Maltose/maltodextrin-binding periplasmic protein,ion transport protein,sodium channel protein type 9 subunit alpha chimera (68 kDa, Protein from Arcobacter butzleri (strain RM4018))
Cardiac sodium channel with flecainide
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 6uz0
Q-score: 0.459
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- Cardiac sodium channel complex with flecainide (250 kDa, Complex from Rattus norvegicus)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Flecainide (414 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6uz3
Q-score: 0.401
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Cardiac sodium channel apo structure (250 kDa, Complex from Rattus norvegicus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6p6w
Q-score: 0.338
Wisedchaisri G, Tonggu L, McCord E, Gamal El-Din TM, Wang L, Zheng N, Catterall WA
Cell (2019) 178 pp. 993- [ Pubmed: 31353218 DOI: doi:10.1016/j.cell.2019.06.031 ]