Cryo-EM structure of Antibody 12-16 in complex with prefusion SARS-CoV-2 Spike glycoprotein
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7ukl
Q-score: 0.49
Liu L, Casner RG, Guo Y, Wang Q, Iketani S, Chan JF, Yu J, Dadonaite B, Nair MS, Mohri H, Reddem ER, Yuan S, Poon VK, Chan CC, Yuen KY, Sheng Z, Huang Y, Bloom JD, Shapiro L, Ho DD
Immunity (2023) 56 pp. 2442- [ DOI: doi:10.1016/j.immuni.2023.09.003 Pubmed: 37776849 ]
- 12-16 fab heavy chain (14 kDa, Protein from Homo sapiens)
- 12-16 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody 12-16 in complex with prefusion sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (focused refinement on Fab-RBD)
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7wh8
Q-score: 0.523
Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2245921-2245921 [ Pubmed: 37542391 DOI: doi:10.1080/22221751.2023.2245921 ]
- Spike glycoprotein (31 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike (Complex)
- Antibody zb8 heavy chain (23 kDa, Protein from Homo sapiens)
- Fab-spike (Complex from Homo sapiens)
- Fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody zb8 light chain (23 kDa, Protein from Homo sapiens)
SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U)
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 7whb
Q-score: 0.479
Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2245921-2245921 [ Pubmed: 37542391 DOI: doi:10.1080/22221751.2023.2245921 ]
- Antibody zb8 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab (Complex)
- Fab-spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody zb8 light chain (23 kDa, Protein from Homo sapiens)
SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (2u1d)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 7whd
Q-score: 0.128
Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2245921-2245921 [ Pubmed: 37542391 DOI: doi:10.1080/22221751.2023.2245921 ]
- Antibody zb8 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab (Complex)
- Fab-spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody zb8 light chain (23 kDa, Protein from Homo sapiens)
The structure of ZCB11 Fab against SARS-CoV-2 Omicron Spike
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 7xh8
Q-score: 0.255
Zhou B, Zhou R, Tang B, Chan JF, Luo M, Peng Q, Yuan S, Liu H, Mok BW, Chen B, Wang P, Poon VK, Chu H, Chan CC, Tsang JO, Chan CC, Au KK, Man HO, Lu L, To KK, Chen H, Yuen KY, Dang S, Chen Z
Nat Commun (2022) 13 pp. 3589-3589 [ DOI: doi:10.1038/s41467-022-31259-7 Pubmed: 35739114 ]
- The zcb11 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- The light chain of zcb11 antibody (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The spike protein of sars-cov-2 omicron variant (Complex)
- The heavy chain of zcb11 antibody (23 kDa, Protein from Homo sapiens)
- The complex of zcb11 against fab sars-cov-2 omicron spike (Complex from Homo sapiens)
The Cryo-EM structure of SARS-CoV-2 Omicron 2-RBD up spike protein complexed with ZCB11 fab
The Cryo-EM structure of SARS-CoV-2 Omicron 3-RBD up spike protein complexed with ZCB11 fab
Broadly Neutralizing Antibody 10-40 in complex with prefusion SARS-CoV-2 B.1.351 Spike glycoprotein
Liu L, Iketani S, Guo Y, Reddem ER, Casner RG, Nair MS, Yu J, Chan JF, Wang M, Cerutti G, Li Z, Morano NC, Castagna CD, Corredor L, Chu H, Yuan S, Poon VK, Chan CC, Chen Z, Luo Y, Cunningham M, Chavez A, Yin MT, Perlin DS, Tsuji M, Yuen KY, Kwong PD, Sheng Z, Huang Y, Shapiro L, Ho DD
Sci Transl Med (2022) 14 pp. eabn6859-eabn6859 [ Pubmed: 35438546 DOI: doi:10.1126/scitranslmed.abn6859 ]