Cryo-EM structure of Ku 70/80 bound to inositol hexakisphosphate
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7zt6
Q-score: 0.387
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB
Nucleic Acids Res (2023) 51 pp. 11732-11747 [ Pubmed: 37870477 DOI: doi:10.1093/nar/gkad863 ]
- Cryo-em structure of ku 70/80 bound to inositol hexakisphosphate (Complex from Homo sapiens)
- X-ray repair cross-complementing protein 6 (73 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
Cryo-EM structure of DNA-PKcs in complex with NU7441
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 7otm
Q-score: 0.394
Liang S, Thomas SE, Chaplin AK, Hardwick SW, Chirgadze DY, Blundell TL
Nature (2022) 601 pp. 643-648 [ Pubmed: 34987222 DOI: doi:10.1038/s41586-021-04274-9 ]
DNA-PKcs in complex with ATPgammaS-Mg
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7otp
Q-score: 0.414
Liang S, Thomas SE, Chaplin AK, Hardwick SW, Chirgadze DY, Blundell TL
Nature (2022) 601 pp. 643-648 [ Pubmed: 34987222 DOI: doi:10.1038/s41586-021-04274-9 ]
- Dna-dependent protein kinase catalytic subunit,dna-pkcs (471 kDa, Protein from Homo sapiens)
- Dna-pkcs in complex with nu7441 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
DNA-PKcs in complex with wortmannin
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7otv
Q-score: 0.308
Liang S, Thomas SE, Chaplin AK, Hardwick SW, Chirgadze DY, Blundell TL
Nature (2022) 601 pp. 643-648 [ Pubmed: 34987222 DOI: doi:10.1038/s41586-021-04274-9 ]
- Dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit,dna-pkcs (471 kDa, Protein from Homo sapiens)
- (1s,6br,9as,11r,11br)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3h-furo[4, 3,2-de]indeno[4,5-h][2]benzopyran-11-yl acetate (428 Da, Ligand)
- Dna-pkcs in complex with wortmannin (Complex from Homo sapiens)
Cryo-EM structure of W107R KatG from M. tuberculosis
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7a2i
Q-score: 0.507
Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK
Structure (2021) 29 pp. 899-912.e4 [ DOI: doi:10.1016/j.str.2020.12.008 Pubmed: 33444527 ]
- Cryo-em structure of w107r katg from m. tuberculosis (161 MDa, Cellular component from Mycobacterium tuberculosis)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Catalase-peroxidase (80 kDa, Protein from Mycobacterium tuberculosis)
Cryo-EM structure of W107R after heme uptake (2heme molecules) KatG from M. tuberculosis
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 7a7a
Q-score: 0.546
Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK
Structure (2021) 29 pp. 899-912.e4 [ DOI: doi:10.1016/j.str.2020.12.008 Pubmed: 33444527 ]
Cryo-EM structure of W107R after heme uptake (1heme molecule) KatG from M. tuberculosis
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7a7c
Q-score: 0.535
Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK
Structure (2021) 29 pp. 899-912.e4 [ DOI: doi:10.1016/j.str.2020.12.008 Pubmed: 33444527 ]
Cryo-EM structure of T275P KatG from M. tuberculosis
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7a8z
Q-score: 0.506
Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK
Structure (2021) 29 pp. 899-912.e4 [ DOI: doi:10.1016/j.str.2020.12.008 Pubmed: 33444527 ]
T275P after heme uptake from M. tuberculosis
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 7aa3
Q-score: 0.5
Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK
Structure (2021) 29 pp. 899-912.e4 [ DOI: doi:10.1016/j.str.2020.12.008 Pubmed: 33444527 ]
Cryo-EM structure of DNA-PKcs (State 2)
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 6zfp
Q-score: 0.472
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL
Nat Struct Mol Biol (2021) 28 pp. 13-19 [ DOI: doi:10.1038/s41594-020-00517-x Pubmed: 33077952 ]
- Dna-pkcs (470 kDa, Cellular component from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-pkcs,dna-pkcs (472 kDa, Protein from Homo sapiens)