DNA-PK Ku80 mediated dimer bound to PAXX
Resolution: 4.55 Å
EM Method: Single-particle
Fitted PDBs: 8bh3
Q-score: 0.185
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ Pubmed: 37256950 DOI: doi:10.1126/sciadv.adg2834 ]
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Nhej supercomplex bound to paxx (1 MDa, Complex from Homo sapiens)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- Dna (28-mer) (8 kDa, DNA from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
DNA-PK XLF mediated dimer bound to PAXX
Resolution: 4.51 Å
EM Method: Single-particle
Fitted PDBs: 8bhv
Q-score: 0.203
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ Pubmed: 37256950 DOI: doi:10.1126/sciadv.adg2834 ]
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- Dna (28-mer) (7 kDa, DNA from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- Dna-pk xlf mediated dimer bound to paxx (1 MDa, Complex from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- Dna (24-mer) (7 kDa, DNA from Homo sapiens)
DNA-PK in complex with ATPgammaS
Liang S, Thomas SE, Chaplin AK, Hardwick SW, Chirgadze DY, Blundell TL
Nature (2022) 601 pp. 643-648 [ Pubmed: 34987222 DOI: doi:10.1038/s41586-021-04274-9 ]
Cryo-EM structure of NHEJ super-complex (dimer)
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 7nfc
Q-score: 0.2
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL
Mol Cell (2021) 81 pp. 3400-3409 [ Pubmed: 34352203 DOI: doi:10.1016/j.molcel.2021.07.005 ]
- Dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit,dna-pkcs (471 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (Cellular component from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Repair protein and ligase (Cellular component from Homo sapiens)
- Nhej super-complex (dimer) (1 MDa, Cellular component)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna (Cellular component from Homo sapiens)
- Dna (28-mer) (8 kDa, DNA from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing proteins 5 and 6 (Cellular component from Homo sapiens)
Cryo-EM structure of NHEJ super-complex (monomer)
Resolution: 4.29 Å
EM Method: Single-particle
Fitted PDBs: 7nfe
Q-score: 0.203
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL
Mol Cell (2021) 81 pp. 3400-3409 [ Pubmed: 34352203 DOI: doi:10.1016/j.molcel.2021.07.005 ]
- Dna-dependent protein kinase catalytic subunit (Cellular component from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit (472 kDa, Protein from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*ap*ap*tp*ap*ap*ap*cp*tp*ap*ap*ap*ap*ap*cp*tp*ap*tp*tp*ap*tp*tp*ap*tp*g)-3') (7 kDa, DNA from Homo sapiens)
- Non-homologous end-joining factor 1,dna repair protein xrcc4, dna ligase 4 (Cellular component from Homo sapiens)
- X-ray repair cross-complementing protein 6 and 5 (Cellular component from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna (Cellular component from Homo sapiens)
- Nhej super-complex (monomer) (800 kDa, Cellular component)
- Dna (5'-d(p*tp*ap*ap*tp*ap*ap*tp*ap*gp*tp*tp*tp*tp*tp*ap*gp*tp*tp*tp*ap*tp*tp*ap*g)-3') (7 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
Cryo-EM structure of DNA-PKcs:DNA
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 6zh8
Q-score: 0.277
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL
Nat Struct Mol Biol (2021) 28 pp. 13-19 [ DOI: doi:10.1038/s41594-020-00517-x Pubmed: 33077952 ]
- Dna (5'-d(p*ap*gp*tp*tp*tp*tp*tp*ap*gp*tp*t)-3') (3 kDa, DNA from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-pkcs (472 kDa, Protein from Homo sapiens)
- Dna-pkcs (Cellular component from Homo sapiens)
- Dna-pkcs bound to dna (480 kDa, Cellular component)
- Dna (5'-d(p*ap*cp*tp*ap*ap*ap*ap*a)-3') (2 kDa, DNA from Homo sapiens)
- Dna (Cellular component from Homo sapiens)