Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8cx0
Q-score: 0.509
Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD
Nature (2023) 615 pp. 728-733 [ Pubmed: 36754086 DOI: doi:10.1038/s41586-023-05779-1 ]
- Rna (5'-r(p*ap*ap*ap*ap*ap*ap*ap*a)-3') (2 kDa, RNA from Spodoptera frugiperda)
- Virion infectivity factor (22 kDa, Protein from Human immunodeficiency virus 1)
- Dna dc->du-editing enzyme apobec-3g (50 kDa, Protein from Homo sapiens)
- Hiv-1 vif-e3 ligase substrate receptor (vcbc) in complex with human apobec3g and rna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Core-binding factor subunit beta (21 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8cx1
Q-score: 0.366
Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD
Nature (2023) 615 pp. 728-733 [ Pubmed: 36754086 DOI: doi:10.1038/s41586-023-05779-1 ]
- Virion infectivity factor (22 kDa, Protein from Human immunodeficiency virus 1)
- Dna dc->du-editing enzyme apobec-3g (50 kDa, Protein from Homo sapiens)
- Hiv-1 vif-e3 ligase substrate receptor (vcbc) in complex with human apobec3g and rna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Core-binding factor subunit beta (21 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*ap*ap*ap*ap*up*ap*up*u)-3') (2 kDa, RNA from Spodoptera frugiperda)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*up*ap*ap*ap*up*ap*up*u)-3') (2 kDa, RNA from Spodoptera frugiperda)
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8cx2
Q-score: 0.375
Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD
Nature (2023) 615 pp. 728-733 [ Pubmed: 36754086 DOI: doi:10.1038/s41586-023-05779-1 ]
- Virion infectivity factor (22 kDa, Protein from Human immunodeficiency virus 1)
- Dna dc->du-editing enzyme apobec-3g (50 kDa, Protein from Homo sapiens)
- Hiv-1 vif-e3 ligase substrate receptor (vcbc) in complex with human apobec3g and rna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Core-binding factor subunit beta (21 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*ap*ap*up*ap*ap*ap*ap*ap*u)-3') (2 kDa, RNA from Spodoptera frugiperda)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*up*up*up*ap*ap*ap*ap*ap*u)-3') (2 kDa, RNA from Spodoptera frugiperda)
Cryo-EM map of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1-prime
Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD
Nature (2023) 615 pp. 728-733 [ Pubmed: 36754086 DOI: doi:10.1038/s41586-023-05779-1 ]