Structure of full-length human cardiac sodium channel - Class-I.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8vyj
Q-score: 0.342
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha (227 kDa, Protein from Homo sapiens)
- Sodium channel protein type 5 subunit alpha (226 kDa, Cellular component from Mammalia)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Structure of full-length human cardiac sodium channel - Class-II.
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vyk
Q-score: 0.304
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha (227 kDa, Protein from Homo sapiens)
- Sodium channel protein type 5 subunit alpha (226 kDa, Cellular component from Mammalia)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Cryo-EM structure of human dysferlin monomer
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 9b8k
Q-score: 0.307
Huang HL, Grandinetti G, Heissler SM, Chinthalapudi K
Nat Commun (2024) 15 pp. 9650-9650 [ DOI: doi:10.1038/s41467-024-53773-6 Pubmed: 39511170 ]
- Dysferlin monomer (237 kDa, Cellular component from unidentified)
- Dysferlin (237 kDa, Protein from Homo sapiens)
Cryo-EM structure of human dysferlin dimer
Resolution: 4.65 Å
EM Method: Single-particle
Fitted PDBs: 9b8l
Q-score: 0.109
Huang HL, Grandinetti G, Heissler SM, Chinthalapudi K
Nat Commun (2024) 15 pp. 9650-9650 [ DOI: doi:10.1038/s41467-024-53773-6 Pubmed: 39511170 ]
- Dysferlin (237 kDa, Protein from Homo sapiens)
- Dysferlin dimer (474 kDa, Cellular component from unidentified)
Resolution: 3.499 Å
EM Method: Single-particle
Fitted PDBs: 8cog
Q-score: 0.491
Pinto CS, Bakker SE, Suchenko A, Hussain H, Hatano T, Sampath K, Chinthalapudi K, Mishima M, Balasubramanian M
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Polymerised arginylated actin with bound adp (Complex from Homo sapiens)
- Actin, cytoplasmic 1, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of skeletal muscle alpha-actin
Resolution: 3.37 Å
EM Method: Helical reconstruction
Fitted PDBs: 8dmx
Q-score: 0.52
Arora AS, Huang HL, Singh R, Narui Y, Suchenko A, Hatano T, Heissler SM, Balasubramanian MK, Chinthalapudi K
eLife (2023) 12 [ DOI: doi:10.7554/eLife.82015 Pubmed: 36790143 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin, alpha skeletal muscle (41 kDa, Protein from rabbit)
- Actin (Cellular component from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of cardiac muscle alpha-actin
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8dmy
Q-score: 0.561
Arora AS, Huang HL, Singh R, Narui Y, Suchenko A, Hatano T, Heissler SM, Balasubramanian MK, Chinthalapudi K
eLife (2023) 12 [ DOI: doi:10.7554/eLife.82015 Pubmed: 36790143 ]
- Actin, alpha cardiac muscle 1 (41 kDa, Protein from cattle)
- Cardiac alpha actin (Cellular component from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Cryo-EM structure of nonmuscle gamma-actin
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8dnf
Q-score: 0.502
Arora AS, Huang HL, Singh R, Narui Y, Suchenko A, Hatano T, Heissler SM, Balasubramanian MK, Chinthalapudi K
eLife (2023) 12 [ DOI: doi:10.7554/eLife.82015 Pubmed: 36790143 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin, cytoplasmic 2, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Actin (Cellular component from Homo sapiens)
Cryo-EM structure of nonmuscle beta-actin
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8dnh
Q-score: 0.456
Arora AS, Huang HL, Singh R, Narui Y, Suchenko A, Hatano T, Heissler SM, Balasubramanian MK, Chinthalapudi K
eLife (2023) 12 [ DOI: doi:10.7554/eLife.82015 Pubmed: 36790143 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Filamentous actin (Cellular component from Homo sapiens)
- Actin, cytoplasmic 1, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Structure of the autoinhibited state of smooth muscle myosin-2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mf3
Q-score: 0.264
Heissler SM, Arora AS, Billington N, Sellers JR, Chinthalapudi K
Sci Adv (2021) 7 pp. eabk3273-eabk3273 [ DOI: doi:10.1126/sciadv.abk3273 Pubmed: 34936462 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Myosin light polypeptide 6 (16 kDa, Protein from Gallus gallus)
- Smooth muscle myosin-2 10s complex (531 kDa, Complex from Gallus gallus)
- Magnesium ion (24 Da, Ligand)
- Myosin-11 (229 kDa, Protein from Gallus gallus)
- Myosin regulatory light chain 2, smooth muscle major isoform (19 kDa, Protein from Gallus gallus)