Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6v3f
Q-score: 0.455
Huang CS, Yu X, Fordstrom P, Choi K, Chung BC, Roh SH, Chiu W, Zhou M, Min X, Wang Z
Sci Adv (2020) 6 pp. eabb1989- [ DOI: doi:10.1126/sciadv.abb1989 ]
- Npc1-like intracellular cholesterol transporter 1 (147 kDa, Protein from Rattus norvegicus)
- Npc1-like intracellular cholesterol transporter 1 (npc1l1) (Cellular component from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6v3h
Q-score: 0.5
Huang CS, Yu X, Fordstrom P, Choi K, Chung BC, Roh SH, Chiu W, Zhou M, Min X, Wang Z
Sci Adv (2020) 6 pp. eabb1989- [ DOI: doi:10.1126/sciadv.abb1989 ]
- Npc1-like intracellular cholesterol transporter 1 (npc1l1) in complex with an inhibitor (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Npc1-like intracellular cholesterol transporter 1 (147 kDa, Protein from Rattus norvegicus)
- 4-[(2s,3r)-3-[(3s)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-{3-[(methylsulfonyl)amino]prop-1-yn-1-yl}phenyl)-4-oxoazetidin-2-yl]phenyl beta-d-glucopyranosiduronic acid (698 Da, Ligand)
Structure of TrkH-TrkA in complex with ATP
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 6v4j
Q-score: 0.337
Zhang H, Pan Y, Hu L, Hudson MA, Hofstetter KS, Xu Z, Rong M, Wang Z, Prasad BVV, Lockless SW, Chiu W, Zhou M
Nat Commun (2020) 11 pp. 547-547 [ DOI: doi:10.1038/s41467-019-14240-9 Pubmed: 31992706 ]
- Trkh-trka (400 kDa, Complex from Vibrio parahaemolyticus RIMD 2210633)
- Trk system potassium uptake protein trkh (53 kDa, Protein from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633))
- Potassium uptake protein trka (50 kDa, Protein from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633))
Open state structure of the full-length TRPV2 cation channel with a resolved pore turret domain
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6bo4
Q-score: 0.347
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol (2019) 26 pp. 40-49 [ DOI: doi:10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
- Transient receptor potential cation channel subfamily v member 2 (79 kDa, Protein from Rattus norvegicus)
- Trpv2 (320 kDa, Complex from Rattus norvegicus)
TRPV2 ion channel in partially closed state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6bo5
Q-score: 0.358
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol (2019) 26 pp. 40-49 [ DOI: doi:10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
Asymmetric structure of AcrAB-TolC tripartite multi drug efflux pump
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 5o66
Q-score: 0.24
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ Pubmed: 28355133 DOI: doi:10.7554/eLife.24905 ]
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli (strain K12))
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli (strain K12))
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli (strain K12))
- Acrabz-tolc (Complex from Escherichia coli K12)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli (strain K12))
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5ng5
Q-score: 0.326
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ Pubmed: 28355133 DOI: doi:10.7554/eLife.24905 ]
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli)
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli)
- Acrabtolc in apo state (Complex from Escherichia coli)
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli)
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5v5s
Q-score: 0.193
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ Pubmed: 28355133 DOI: doi:10.7554/eLife.24905 ]
- Multidrug efflux pump subunit acra (42 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (48 kDa, Protein from Escherichia coli)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli )
- Acrabtolc in apo state (Complex from Escherichia coli)
Bacteriophage P22 mature virion capsid protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 5uu5
Q-score: 0.548
Hryc CF, Chen DH, Afonine PV, Jakana J, Wang Z, Haase-Pettingell C, Jiang W, Adams PD, King JA, Schmid MF, Chiu W
PNAS (2017) 114 pp. 3103-3108 [ DOI: doi:10.1073/pnas.1621152114 Pubmed: 28270620 ]
- Enterobacteria phage p22 (327 MDa, Virus from Enterobacteria phage P22)
- Major capsid protein (46 kDa, Protein from Salmonella phage P22)
Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 3jav
Q-score: 0.219
Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II
Nature (2015) 527 pp. 336-341 [ DOI: doi:10.1038/nature15249 Pubmed: 26458101 ]
- Inositol 1,4,5-trisphosphate receptor (300 kDa, Protein from Rattus norvegicus)
- Inositol 1,4,5-trisphosphate receptor, type 1 (1 MDa, Sample)