Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8ta2
Q-score: 0.557
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90648 Pubmed: 38345841 ]
- 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid (389 Da, Ligand)
- Chloride channel protein 2 (52 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Chloride channel protein 2 with inhibitor ak-42 (Complex from Homo sapiens)
Resolution: 2.46 Å
EM Method: Single-particle
Fitted PDBs: 8ta3
Q-score: 0.635
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90648 Pubmed: 38345841 ]
- Chloride channel protein 2 (Complex from Homo sapiens)
- Chloride channel protein 2 (95 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8ta4
Q-score: 0.59
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90648 Pubmed: 38345841 ]
- Chloride channel protein 2 (Complex from Homo sapiens)
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8ta5
Q-score: 0.36
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90648 Pubmed: 38345841 ]
- Chloride channel protein 2 (Complex from Homo sapiens)
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain
Resolution: 4.03 Å
EM Method: Single-particle
Fitted PDBs: 8ta6
Q-score: 0.37
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90648 Pubmed: 38345841 ]
- Chloride channel protein 2 (Complex from Homo sapiens)
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
Asymmetric structure of AcrAB-TolC tripartite multi drug efflux pump
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 5o66
Q-score: 0.24
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ Pubmed: 28355133 DOI: doi:10.7554/eLife.24905 ]
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli (strain K12))
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli (strain K12))
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli (strain K12))
- Acrabz-tolc (Complex from Escherichia coli K12)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli (strain K12))
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5ng5
Q-score: 0.326
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ Pubmed: 28355133 DOI: doi:10.7554/eLife.24905 ]
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli)
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli)
- Acrabtolc in apo state (Complex from Escherichia coli)
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli)
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5v5s
Q-score: 0.193
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ Pubmed: 28355133 DOI: doi:10.7554/eLife.24905 ]
- Multidrug efflux pump subunit acra (42 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (48 kDa, Protein from Escherichia coli)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli )
- Acrabtolc in apo state (Complex from Escherichia coli)