Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6m0r
Q-score: 0.467
Roh SH, Shekhar M, Pintilie G, Chipot C, Wilkens S, Singharoy A, Chiu W
Sci Adv (2020) 6 [ Pubmed: 33028525 DOI: doi:10.1126/sciadv.abb9605 ]
- V-type proton atpase vo sub-complex (400 MDa, Complex from Saccharomyces cerevisiae)
- V-type proton atpase subunit c (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V-type proton atpase subunit d (39 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V-type proton atpase subunit c' (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V0 assembly protein 1 (5 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- V-type proton atpase subunit c'' (20 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Pyrophosphate (177 Da, Ligand)
- V-type proton atpase subunit e (8 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Uncharacterized protein ypr170w-b (7 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V-type proton atpase subunit a, vacuolar isoform (94 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- (6~{e},10~{e},14~{e},18~{e},22~{e},26~{e},30~{r})-2,6,10,14,18,22,26,30-octamethyldotriaconta-2,6,10,14,18,22,26-heptaene (548 Da, Ligand)
- Water (18 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6m0s
Q-score: 0.384
Roh SH, Shekhar M, Pintilie G, Chipot C, Wilkens S, Singharoy A, Chiu W
Sci Adv (2020) 6 [ Pubmed: 33028525 DOI: doi:10.1126/sciadv.abb9605 ]
- V-type proton atpase vo sub-complex (400 MDa, Complex from Saccharomyces cerevisiae)
- V-type proton atpase subunit d (39 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V-type proton atpase subunit c (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V-type proton atpase subunit c' (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V0 assembly protein 1 (5 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V-type proton atpase subunit c'' (20 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V-type proton atpase subunit e (8 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Uncharacterized protein ypr170w-b (7 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- V-type proton atpase subunit a, vacuolar isoform (94 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6v3f
Q-score: 0.455
Huang CS, Yu X, Fordstrom P, Choi K, Chung BC, Roh SH, Chiu W, Zhou M, Min X, Wang Z
Sci Adv (2020) 6 pp. eabb1989- [ DOI: doi:10.1126/sciadv.abb1989 ]
- Npc1-like intracellular cholesterol transporter 1 (147 kDa, Protein from Rattus norvegicus)
- Npc1-like intracellular cholesterol transporter 1 (npc1l1) (Cellular component from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6v3h
Q-score: 0.5
Huang CS, Yu X, Fordstrom P, Choi K, Chung BC, Roh SH, Chiu W, Zhou M, Min X, Wang Z
Sci Adv (2020) 6 pp. eabb1989- [ DOI: doi:10.1126/sciadv.abb1989 ]
- Npc1-like intracellular cholesterol transporter 1 (npc1l1) in complex with an inhibitor (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Npc1-like intracellular cholesterol transporter 1 (147 kDa, Protein from Rattus norvegicus)
- 4-[(2s,3r)-3-[(3s)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-{3-[(methylsulfonyl)amino]prop-1-yn-1-yl}phenyl)-4-oxoazetidin-2-yl]phenyl beta-d-glucopyranosiduronic acid (698 Da, Ligand)