Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8u26
Q-score: 0.572
Nat Methods (2024) 21 pp. 37-40 [ DOI: doi:10.1038/s41592-023-02082-9 Pubmed: 37973972 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Substance p bound to active human neurokinin 1 receptor in complex with minigs399 (141 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Protachykinin-1 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Substance-p receptor (47 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8u28
Q-score: 0.464
Nat Methods (2024) 21 pp. 37-40 [ DOI: doi:10.1038/s41592-023-02082-9 Pubmed: 37973972 ]
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8u2c
Q-score: 0.534
Nat Methods (2024) 21 pp. 37-40 [ DOI: doi:10.1038/s41592-023-02082-9 Pubmed: 37973972 ]
- Inhibitor-bound abcg2 (Complex from Homo sapiens)
- Fab heavy chain constant domain (22 kDa, Protein from Homo sapiens)
- 5d3 fab light chain variable domain (23 kDa, Protein from Mus musculus)
- Broad substrate specificity atp-binding cassette transporter abcg2 (72 kDa, Protein from Homo sapiens)
- 5d3 fab heavy chain variable domain (23 kDa, Protein from Mus musculus)
- Fab light chain constant domain (22 kDa, Protein from Homo sapiens)
Singapore Grouper Iridovirus (SGIV) at 8.6 Angstrom Resolution
Resolution: 8.6 Å
EM Method: Single-particle
Fitted PDBs: 6ojn
Q-score: 0.08
Pintilie G, Chen DH, Tran BN, Jakana J, Wu J, Hew CL, Chiu W
Structure (2019) 27 pp. 1561- [ Pubmed: 31447288 DOI: doi:10.1016/j.str.2019.08.002 ]
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5ng5
Q-score: 0.326
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ Pubmed: 28355133 DOI: doi:10.7554/eLife.24905 ]
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli)
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli)
- Acrabtolc in apo state (Complex from Escherichia coli)
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli)
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5v5s
Q-score: 0.193
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ Pubmed: 28355133 DOI: doi:10.7554/eLife.24905 ]
- Multidrug efflux pump subunit acra (42 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (48 kDa, Protein from Escherichia coli)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli )
- Acrabtolc in apo state (Complex from Escherichia coli)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 3j3x
Q-score: 0.169
DiMaio F, Zhang J, Chiu W, Baker D
Protein Sci (2013) 22 pp. 865-868 [ Pubmed: 23592445 DOI: doi:10.1002/pro.2267 ]
- Chaperonin (960 kDa, Protein from Methanococcus maripaludis)
- Mm-cpn with 1mm atp/alfx (960 kDa, Sample)
cryo-EM structure of CCT5 complex with 1mM ATP/AlFx (C8 symmetry)
Sergeeva OA, Chen B, Haase-Pettingell C, Ludtke SJ, Chiu W, King JA
J Biol Chem (2013) 288 pp. 17734-17744 [ DOI: doi:10.1074/jbc.M112.443929 Pubmed: 23612981 ]
- Cct5 complex (1 MDa, Sample)
- Chaperonin containing tcp1, subunit 5 (epsilon) (1 MDa, Protein from Homo sapiens)
Lidless D386A Mm-cpn in the pre-hydrolysis ATP-bound state
Resolution: 8.0 Å
EM Method: Single-particle
Fitted PDBs: 3j02
Q-score: 0.079
Zhang J, Ma B, DiMaio F, Douglas NR, Joachimiak LA, Baker D, Frydman J, Levitt M, Chiu W
Structure (2011) 19 pp. 633-639 [ Pubmed: 21565698 DOI: doi:10.1016/j.str.2011.03.005 ]
- Lidless d386a mm-cpn variant (1 MDa, Sample)
- Methanococcus maripaludis chaperonin (1 MDa, Protein from Methanococcus maripaludis)
Resolution: 11.0 Å
EM Method: Single-particle
Fitted PDBs: 3izh
Q-score: 0.034
Douglas NR, Reissmann S, Zhang J, Chen B, Jakana J, Kumar R, Chiu W, Frydman J
Cell (2011) 144 pp. 240-252 [ DOI: doi:10.1016/j.cell.2010.12.017 Pubmed: 21241893 ]
- Chaperonin (900 kDa, Protein from Methanococcus maripaludis)
- Mm-cpn d386a with atp (900 kDa, Sample)