Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 9are
Q-score: 0.362
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 9arf
Q-score: 0.473
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Rat glun1-glu2b di-heterotetrameric nmda receptor channel (400 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Rat GluN1-GluN2B NMDA receptor channel in apo conformation
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 9arg
Q-score: 0.292
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
Rat GluN1-GluN2B NMDA receptor channel in complex with glycine
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 9arh
Q-score: 0.419
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Isoform b of glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Glycine (75 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
Rat GluN1-GluN2B NMDA receptor channel in complex with glutamate
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9ari
Q-score: 0.342
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glutamic acid (147 Da, Ligand)
- Isoform b of glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 9bib
Q-score: 0.341
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamate receptor (98 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
Movies of Glycine/Glutamate bound GluN1a-GluN2D NMDAR
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H
Mol Cell (2022) 82 pp. 4548-4563.e4 [ DOI: 10.1016/j.molcel.2022.10.008 Pubmed: 36309015 ]
Image sets:
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 8e92
Q-score: 0.397
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H
Mol Cell (2022) 82 pp. 4548- [ DOI: doi:10.1016/j.molcel.2022.10.008 Pubmed: 36309015 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hetero-tetrameric glun1a-glun2c nmda receptors (Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2c (96 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8e93
Q-score: 0.443
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H
Mol Cell (2022) 82 pp. 4548- [ DOI: doi:10.1016/j.molcel.2022.10.008 Pubmed: 36309015 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hetero-tetrameric glun1a-glun2c nmda receptors (Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2c (96 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8e94
Q-score: 0.47
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H
Mol Cell (2022) 82 pp. 4548- [ Pubmed: 36309015 DOI: doi:10.1016/j.molcel.2022.10.008 ]
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2c (96 kDa, Protein from Homo sapiens)
- Methyl 4-[(2~{r})-3-ethanoyl-1-[2-(2-methyl-1~{h}-indol-3-yl)ethyl]-4-oxidanyl-5-oxidanylidene-2~{h}-pyrrol-2-yl]benzoate (432 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hetero-tetrameric glun1a-glun2c nmda receptors (Complex from Homo sapiens)