CRF1 Receptor Gs GPCR protein complex with CRF1 peptide.
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 6p9x
Q-score: 0.58
Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D
Mol Cell (2020) 77 pp. 656-668.e5 [ DOI: doi:10.1016/j.molcel.2020.01.012 Pubmed: 32004469 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, corticotropin-releasing factor receptor 1 (Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Corticoliberin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Corticotropin-releasing factor receptor 1 (49 kDa, Protein from Homo sapiens)
- Complex of active-state corticotropin-releasing hormone receptor 1 with heterotrimeric gs protein. (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Corticoliberin (4 kDa, Protein from Homo sapiens)
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 6p9y
Q-score: 0.545
Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D
Mol Cell (2020) 77 pp. 656-668.e5 [ DOI: doi:10.1016/j.molcel.2020.01.012 Pubmed: 32004469 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Pituitary adenylate cyclase-activating polypeptide type i receptor (Complex from Homo sapiens)
- Pituitary adenylate cyclase-activating polypeptide (4 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Pituitary adenylate cyclase-activating polypeptide type i receptor (55 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, pituitary adenylate cyclase-activating polypeptide (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Complex of active-state pituitary adenylate cyclase-activating polypeptide type i receptor with heterotrimeric gs protein. (Complex)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 5uz7
Q-score: 0.413
Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM
Nature (2017) 546 pp. 118-123 [ DOI: doi:10.1038/nature22327 Pubmed: 28437792 ]
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama Glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Complex of a full-length, active-state calcitonin receptor with peptide ligand, heterotrimeric gs protein and nano body 35. (150 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)