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primary_citation_author:"Ciesielski F"
CryoEM structure of Gs-coupled GPBAR with small molecule agonist P395
Release date: Oct. 9, 2024
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9gyo
Q-score: 0.629
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9gyo
Q-score: 0.629
Castel J, Botzanowski T, Brooks I, Frechard A, Bey G, Schroeter M, Del nero E, Debaene F, Ciesielski F, Zeyer D, Cianferani S, Morales R
To Be Published
Sample:
- Complex of the tgr5 with gs protein heterotrimer, nanobody 35 and small molecule agonist p395 (Complex from Homo sapiens)
- 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5h-pyrido[4,3-d]pyrimidine-4-carboxamide (395 Da, Ligand)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,g-protein coupled bile acid receptor 1 (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)