Cryo-EM consensus map of the GPR55-G13-complex bound to synthetic agonist ML184
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D
Nat Commun (2025) 16 pp. 1973-1973 [ Pubmed: 40000629 DOI: doi:10.1038/s41467-025-57204-y ]
Cryo-EM GPCR focused map of the GPR55-G13-complex bound to synthetic agonist ML184
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D
Nat Commun (2025) 16 pp. 1973-1973 [ Pubmed: 40000629 DOI: doi:10.1038/s41467-025-57204-y ]
Cryo-EM G protein focused map of the GPR55-G13-complex bound to synthetic agonist ML184
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D
Nat Commun (2025) 16 pp. 1973-1973 [ Pubmed: 40000629 DOI: doi:10.1038/s41467-025-57204-y ]
Structure of GPR55 in complex with G13 and synthetic agonist ML184
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D
Nat Commun (2025) 16 pp. 1973-1973 [ Pubmed: 40000629 DOI: doi:10.1038/s41467-025-57204-y ]
- Guanine nucleotide-binding protein subunit alpha-13 (26 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Green fluorescent protein,g-protein coupled receptor 55 (73 kDa, Protein from Homo sapiens)
- Single-chain variable fragment scfv16 (Complex from Mus musculus)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 3-[4-(2,3-dimethylphenyl)piperazin-1-yl]carbonyl-n,n-dimethyl-4-pyrrolidin-1-yl-benzenesulfonamide (470 Da, Ligand)
- Guanine nucleotide-binding proteins (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- G-protein coupled receptor 55 with a gfp tag (Complex from Aequorea victoria)
- Structure of gpr55 in complex with g13 and synthetic agonist ml184 (180 kDa, Complex)
Cryo-EM consensus map of the GPR55-G13-complex bound to lysophosphatidylinositol
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D
Nat Commun (2025) 16 pp. 1973-1973 [ Pubmed: 40000629 DOI: doi:10.1038/s41467-025-57204-y ]
Cryo-EM GPCR focused map of the GPR55-G13-complex bound to lysophosphatidylinositol.
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D
Nat Commun (2025) 16 pp. 1973-1973 [ Pubmed: 40000629 DOI: doi:10.1038/s41467-025-57204-y ]
Cryo-EM G protein focused map of the GPR55-G13-complex bound to lysophosphatidylinositol
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D
Nat Commun (2025) 16 pp. 1973-1973 [ Pubmed: 40000629 DOI: doi:10.1038/s41467-025-57204-y ]
Structure of GPR55 in complex with G13 and endogenous lipid agonist lysophosphatidylinositol
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D
Nat Commun (2025) 16 pp. 1973-1973 [ Pubmed: 40000629 DOI: doi:10.1038/s41467-025-57204-y ]
- Guanine nucleotide-binding protein subunit alpha-13 (26 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- [(2r)-2-oxidanyl-3-[oxidanyl-[(2r,3s,5r,6r)-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] hexadecanoate (572 Da, Ligand)
- Green fluorescent protein,g-protein coupled receptor 55 (73 kDa, Protein from Homo sapiens)
- Single-chain variable fragment scfv16 (Complex from Mus musculus)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding proteins (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 55 with a gfp tag (Complex from Aequorea victoria)
- Gpr55 in complex with heterotrimeric g13 protein and endogenous lipid agonist lysophosphatidylinositol (180 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)