Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8tpw
Q-score: 0.423
Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C
Nat Chem Biol (2024) [ Pubmed: 39179672 DOI: doi:10.1038/s41589-024-01709-y ]
- Antibody fragment 1b2, light chain (25 kDa, Protein from Homo sapiens)
- Antibody fragment 1b2, heavy chain (26 kDa, Protein from Homo sapiens)
- Eryaii,eryaii,eryaii,eryaii,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 (186 kDa, Protein from Saccharopolyspora erythraea)
- Crosslinked debs module 3 in complex with antibody fragment 1b2 (420 kDa, Complex from Saccharopolyspora erythraea)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tpx
Q-score: 0.396
Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C
Nat Chem Biol (2024) [ Pubmed: 39179672 DOI: doi:10.1038/s41589-024-01709-y ]
- Antibody fragment 1b2, light chain (25 kDa, Protein from Homo sapiens)
- Antibody fragment 1b2, heavy chain (26 kDa, Protein from Homo sapiens)
- Eryaii,eryaii,eryaii,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 (186 kDa, Protein from Saccharopolyspora erythraea)
- Crosslinked debs module 3 in complex with antibody fragment 1b2 (420 kDa, Complex from Saccharopolyspora erythraea)
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8tko
Q-score: 0.493
Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C
Nat Chem Biol (2024) [ Pubmed: 39179672 DOI: doi:10.1038/s41589-024-01709-y ]
- Eryai (20 kDa, Protein from Saccharopolyspora erythraea)
- Ks-at core of debs module 3 crosslinked with its translocation acp partner of module 2 (220 kDa, Complex from Saccharopolyspora erythraea)
- Eryaii (99 kDa, Protein from Saccharopolyspora erythraea)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8tjn
Q-score: 0.364
Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C
Nat Chem Biol (2024) [ Pubmed: 39179672 DOI: doi:10.1038/s41589-024-01709-y ]
- Crosslinked debs module 1 in complex with antibody fragment 1b2 (480 kDa, Complex from Saccharopolyspora erythraea)
- Antibody fragment 1b2, heavy chain (26 kDa, Protein from Homo sapiens)
- Eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 (188 kDa, Protein from Saccharopolyspora erythraea)
- Antibody fragment 1b2, light chain (25 kDa, Protein from Homo sapiens)
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8tjo
Q-score: 0.365
Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C
Nat Chem Biol (2024) [ Pubmed: 39179672 DOI: doi:10.1038/s41589-024-01709-y ]
- Crosslinked debs module 1 in complex with antibody fragment 1b2 (480 kDa, Complex from Saccharopolyspora erythraea)
- Antibody fragment 1b2, heavy chain (26 kDa, Protein from Homo sapiens)
- Eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 (188 kDa, Protein from Saccharopolyspora erythraea)
- Antibody fragment 1b2, light chain (25 kDa, Protein from Homo sapiens)
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8tjp
Q-score: 0.388
Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C
Nat Chem Biol (2024) [ Pubmed: 39179672 DOI: doi:10.1038/s41589-024-01709-y ]
6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7m7e
Q-score: 0.449
Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C
Science (2021) 374 pp. 729-734 [ Pubmed: 34735239 DOI: doi:10.1126/science.abi8358 ]
- Complex between debs m3/1te and antibody fragment 1b2 (430 kDa, Complex from Saccharopolyspora erythraea)
- 1b2 (light chain) (25 kDa, Protein from Homo sapiens)
- 6-deoxyerythronolide-b synthase erya2, modules 3 and 4,eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 chimera (187 kDa, Protein from Saccharopolyspora erythraea)
- 1b2 (heavy chain) (26 kDa, Protein from Homo sapiens)
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7m7f
Q-score: 0.403
Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C
Science (2021) 374 pp. 729-734 [ Pubmed: 34735239 DOI: doi:10.1126/science.abi8358 ]
- 1b2 (heavy chain) (26 kDa, Protein from Homo sapiens)
- Complex between debs (3)m1te and antibody fragment 1b2 (480 kDa, Complex from Saccharopolyspora erythraea)
- N~3~-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-n-(2-sulfanylethyl)-beta-alaninamide (358 Da, Ligand)
- Eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 chimera (188 kDa, Protein from Saccharopolyspora erythraea)
- 1b2 (light chain) (25 kDa, Protein from Homo sapiens)
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 2
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7m7g
Q-score: 0.181
Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C
Science (2021) 374 pp. 729-734 [ Pubmed: 34735239 DOI: doi:10.1126/science.abi8358 ]
- 1b2 (heavy chain) (26 kDa, Protein from Homo sapiens)
- Complex between debs (3)m1te and antibody fragment 1b2 (480 kDa, Complex from Saccharopolyspora erythraea)
- Eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 chimera (188 kDa, Protein from Saccharopolyspora erythraea)
- 1b2 (light chain) (25 kDa, Protein from Homo sapiens)
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1'
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7m7h
Q-score: 0.19
Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C
Science (2021) 374 pp. 729-734 [ Pubmed: 34735239 DOI: doi:10.1126/science.abi8358 ]
- 1b2 (heavy chain) (26 kDa, Protein from Homo sapiens)
- Complex between debs (3)m1te and antibody fragment 1b2 (480 kDa, Complex from Saccharopolyspora erythraea)
- Eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 chimera (188 kDa, Protein from Saccharopolyspora erythraea)
- 1b2 (light chain) (25 kDa, Protein from Homo sapiens)