The spike complex of the Lujo Virus
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8p4t
Q-score: 0.481
Eilon-Ashkenazy M, Cohen-Dvashi H, Borni S, Shaked R, Calinsky R, Levy Y, Diskin R
Nat Commun (2024) 15 pp. 7175-7175 [ DOI: doi:10.1038/s41467-024-51606-0 Pubmed: 39169025 ]
- Spike complex from the lujo virus (Complex from Lujo mammarenavirus)
- Glycoprotein (6 kDa, Protein from Mammarenavirus lujoense)
- Glycoprotein (28 kDa, Protein from Mammarenavirus lujoense)
- Glycoprotein (19 kDa, Protein from Mammarenavirus lujoense)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Structure of the membrane soluble spike complex from the Lassa virus in a C3-symmetric map
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7puy
Q-score: 0.417
Katz M, Weinstein J, Eilon-Ashkenazy M, Gehring K, Cohen-Dvashi H, Elad N, Fleishman SJ, Diskin R
Nature (2022) 603 pp. 174-179 [ DOI: doi:10.1038/s41586-022-04429-2 Pubmed: 35173332 ]
- Pre-glycoprotein polyprotein gp complex (29 kDa, Protein from Lassa virus (strain Mouse/Sierra Leone/Josiah/1976))
- The complete spike complex (Complex from Lassa virus Josiah)
- Glycoprotein g2 (28 kDa, Protein from Lassa virus (strain Mouse/Sierra Leone/Josiah/1976))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7pvd
Q-score: 0.383
Katz M, Weinstein J, Eilon-Ashkenazy M, Gehring K, Cohen-Dvashi H, Elad N, Fleishman SJ, Diskin R
Nature (2022) 603 pp. 174-179 [ DOI: doi:10.1038/s41586-022-04429-2 Pubmed: 35173332 ]
- Pre-glycoprotein polyprotein gp complex (29 kDa, Protein from Lassa virus (strain Mouse/Sierra Leone/Josiah/1976))
- The complete spike complex (Complex from Lassa virus Josiah)
- Glycoprotein g2 (28 kDa, Protein from Lassa virus (strain Mouse/Sierra Leone/Josiah/1976))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
C3-focused map on the ectodomain of the Lassa virus spike complex
Katz M, Weinstein J, Eilon-Ashkenazy M, Gehring K, Cohen-Dvashi H, Elad N, Fleishman SJ, Diskin R
Nature (2022) 603 pp. 174-179 [ DOI: doi:10.1038/s41586-022-04429-2 Pubmed: 35173332 ]
Structure of ZEBOV GP in complex with 1T0227 antibody
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 6s8d
Q-score: 0.476
Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R
Cell Host Microbe (2020) 27 pp. 418-427.e4 [ DOI: doi:10.1016/j.chom.2020.01.007 Pubmed: 32059794 ]
- Ebov-gp (Complex from Ebola virus)
- Light chain (23 kDa, Protein from Homo sapiens)
- 1t0227 antibody (Complex from Homo sapiens)
- Ebov-gp in complex with 1t0227 antibody (Complex)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Envelope glycoprotein (35 kDa, Protein from Ebola virus)
- Heavy chain (24 kDa, Protein from Homo sapiens)
Structure of ZEBOV GP in complex with 3T0265 antibody
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 6s8i
Q-score: 0.517
Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R
Cell Host Microbe (2020) 27 pp. 418-427.e4 [ DOI: doi:10.1016/j.chom.2020.01.007 Pubmed: 32059794 ]
- Ebov-gp (Complex from Ebola virus)
- Ebov-gp in complex with 3t0265 antibody (Complex)
- 3t0265 antibody (Complex from Homo sapiens)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Heavy chain (23 kDa, Protein from Homo sapiens)
- Enveloped glycoprotein 1 (35 kDa, Protein from Ebola virus)
- Light chain (23 kDa, Protein from Homo sapiens)
Structure of ZEBOV GP in complex with 5T0180 antibody
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 6s8j
Q-score: 0.554
Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R
Cell Host Microbe (2020) 27 pp. 418-427.e4 [ DOI: doi:10.1016/j.chom.2020.01.007 Pubmed: 32059794 ]
- Envelope glycoprotein 1 (35 kDa, Protein from Ebola virus)
- Ebov-gp (Complex from Ebola virus)
- Heavy chain (24 kDa, Protein from Homo sapiens)
- Ebov-gp in complex with 3t0265 antibody (Complex)
- Water (18 Da, Ligand)
- 5t0180 antibody (Complex from Homo sapiens)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Light chain (23 kDa, Protein from Homo sapiens)
EM structure of a EBOV-GP bound to 3T0331 neutralizing antibody
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6qd7
Q-score: 0.386
Ehrhardt SA, Zehner M, Krahling V, Cohen-Dvashi H, Kreer C, Elad N, Gruell H, Ercanoglu MS, Schommers P, Gieselmann L, Eggeling R, Dahlke C, Wolf T, Pfeifer N, Addo MM, Diskin R, Becker S, Klein F
Nat Med (2019) 25 pp. 1589-1600 [ Pubmed: 31591605 DOI: doi:10.1038/s41591-019-0602-4 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ebov-gp (Complex from Ebola virus)
- Envelope glycoprotein,virion spike glycoprotein,ebov-gp1 (34 kDa, Protein from Ebola virus)
- Neutralizing 3t0331 antibody (Complex from Homo sapiens)
- Heavy chain (23 kDa, Protein from Homo sapiens)
- Light chain (23 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Ebov-gp in complex with neutralizing 3t0331 antibody (Complex)
EM structure of a EBOV-GP bound to 4M0368 neutralizing antibody
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6qd8
Q-score: 0.385
Diskin R, Cohen-Dvashi H, Ehrhardt S, Zehner M, Krahling V, Kreer C, Dahlke C, Ercanoglu MS, Gruell H, Addo MM, Becker S, Klein F
Nat Med (2019) [ ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ebov-gp (Complex from Ebola virus)
- Envelope glycoprotein,virion spike glycoprotein,ebov-gp1 (34 kDa, Protein from Ebola virus)
- Light chain (23 kDa, Protein from Homo sapiens)
- Neutralizing 3t0331 antibody (Complex from Homo sapiens)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Ebov-gp in complex with neutralizing 3t0331 antibody (Complex)
- Heavy chain (23 kDa, Protein from Homo sapiens)