Yang P, Li W, Fan X, Pan J, Mann CJ, Varnum H, Clark LE, Clark SA, Coscia A, Basu H, Smith KN, Brusic V, Abraham J
Nat Commun (2024) 15 pp. 6548-6548 [ Pubmed: 39095394 DOI: doi:10.1038/s41467-024-50887-9 ]
- Eeev strain pe6 mature capsid protein (Complex from Eastern equine encephalitis virus)
- Eeev strain pe6 mature glycoprotein e3 (Complex from Eastern equine encephalitis virus)
- Eastern equine encephalitis virus (Virus from Eastern equine encephalitis virus)
- Eeev strain pe6 mature glycoprotein e1 (Complex from Eastern equine encephalitis virus)
- Eeev strain pe6 mature glycoprotein e2 (Complex from Eastern equine encephalitis virus)
- Vldlr (Complex from Homo sapiens)
Structure of eastern equine encephalitis virus VLP in complex with VLDLR LA1
Yang P, Li W, Fan X, Pan J, Mann CJ, Varnum H, Clark LE, Clark SA, Coscia A, Basu H, Smith KN, Brusic V, Abraham J
Nat Commun (2024) 15 pp. 6548-6548 [ Pubmed: 39095394 DOI: doi:10.1038/s41467-024-50887-9 ]
- Envelope glycoprotein e3 (7 kDa, Protein from Eastern equine encephalitis virus)
- Envelope glycoprotein e2 (47 kDa, Protein from Eastern equine encephalitis virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Eeev strain pe6 mature capsid protein (Complex from Eastern equine encephalitis virus)
- Eeev strain pe6 mature glycoprotein e3 (Complex from Eastern equine encephalitis virus)
- Eastern equine encephalitis virus (Virus from Eastern equine encephalitis virus)
- Eeev strain pe6 mature glycoprotein e1 (Complex from Eastern equine encephalitis virus)
- Eeev strain pe6 mature glycoprotein e2 (Complex from Eastern equine encephalitis virus)
- Vldlr (Complex from Homo sapiens)
- Envelope glycoprotein e1 (47 kDa, Protein from Eastern equine encephalitis virus)
- Capsid protein (29 kDa, Protein from Eastern equine encephalitis virus)
- Calcium ion (40 Da, Ligand)
- Very low-density lipoprotein receptor (4 kDa, Protein from Homo sapiens)
Structure of eastern equine encephalitis virus VLP unliganded quasi-threefold spike protein
Yang P, Li W, Fan X, Pan J, Mann CJ, Varnum H, Clark LE, Clark SA, Coscia A, Basu H, Smith KN, Brusic V, Abraham J
Nat Commun (2024) 15 pp. 6548-6548 [ Pubmed: 39095394 DOI: doi:10.1038/s41467-024-50887-9 ]
- Envelope glycoprotein e1 (47 kDa, Protein from Eastern equine encephalitis virus)
- Structural polyprotein (46 kDa, Protein from Eastern equine encephalitis virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Capsid protein (29 kDa, Protein from Eastern equine encephalitis virus)
- Eastern equine encephalitis virus (Virus from Eastern equine encephalitis virus)
- Structural polyprotein (6 kDa, Protein from Eastern equine encephalitis virus)
Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7sn2
Q-score: 0.399
Nabel KG, Clark SA, Shankar S, Pan J, Clark LE, Yang P, Coscia A, McKay LGA, Varnum HH, Brusic V, Tolan NV, Zhou G, Desjardins M, Turbett SE, Kanjilal S, Sherman AC, Dighe A, LaRocque RC, Ryan ET, Tylek C, Cohen-Solal JF, Darcy AT, Tavella D, Clabbers A, Fan Y, Griffiths A, Correia IR, Seagal J, Baden LR, Charles RC, Abraham J
Science (2022) 375 pp. eabl6251-eabl6251 [ Pubmed: 34855508 DOI: doi:10.1126/science.abl6251 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c1c-a3 fab light chain (25 kDa, Protein from Homo sapiens)
- Sars-cov-2_hexapro in complex with neutralizing antibody c1c-a3 fab from human patient (50 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein sars-cov-2 hexapro (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c1c-a3 fab heavy chain (27 kDa, Protein from Homo sapiens)
- C1c-a3 fab (Complex from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7sn3
Q-score: 0.451
Nabel KG, Clark SA, Shankar S, Pan J, Clark LE, Yang P, Coscia A, McKay LGA, Varnum HH, Brusic V, Tolan NV, Zhou G, Desjardins M, Turbett SE, Kanjilal S, Sherman AC, Dighe A, LaRocque RC, Ryan ET, Tylek C, Cohen-Solal JF, Darcy AT, Tavella D, Clabbers A, Fan Y, Griffiths A, Correia IR, Seagal J, Baden LR, Charles RC, Abraham J
Science (2022) 375 pp. eabl6251-eabl6251 [ Pubmed: 34855508 DOI: doi:10.1126/science.abl6251 ]
- Sars-cov-2 spike protein trimer in complex with human patient antibody c1c-a3 fab (50 kDa, Complex from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c1c-a3 light chain variable region (25 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c1c-a3 heavy chain variable region (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C1c-a3 fab (variable region) (Complex)