Catalytic domain of Dihydrolipoamide Succinytransferase
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 9dz8
Q-score: 0.592
Carr KD, Zambrano DD, Weidle C, Goodson A, Eisenach HE, Pyles H, Courbet A, King NP, Borst AJ
To Be Published
Accurate computational design of genetically encoded 3D protein crystals
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8cwy
Q-score: 0.452
Li Z, Wang S, Nattermann U, Bera AK, Borst AJ, Yaman MY, Bick MJ, Yang EC, Sheffler W, Lee B, Seifert S, Hura GL, Nguyen H, Kang A, Dalal R, Lubner JM, Hsia Y, Haddox H, Courbet A, Dowling Q, Miranda M, Favor A, Etemadi A, Edman NI, Yang W, Weidle C, Sankaran B, Negahdari B, Ross MB, Ginger DS, Baker D
Nat Mater (2023) 22 pp. 1556-1563 [ Pubmed: 37845322 DOI: doi:10.1038/s41563-023-01683-1 ]
- T32-15-1 (49 kDa, Protein from synthetic construct)
- T32-15 (Complex from Escherichia coli)
- T32-15-2 (9 kDa, Protein from synthetic construct)
CryoEM Structure of Computationally Designed Nanocage O32-ZL4
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8szz
Q-score: 0.591
Li Z, Wang S, Nattermann U, Bera AK, Borst AJ, Yaman MY, Bick MJ, Yang EC, Sheffler W, Lee B, Seifert S, Hura GL, Nguyen H, Kang A, Dalal R, Lubner JM, Hsia Y, Haddox H, Courbet A, Dowling Q, Miranda M, Favor A, Etemadi A, Edman NI, Yang W, Weidle C, Sankaran B, Negahdari B, Ross MB, Ginger DS, Baker D
Nat Mater (2023) 22 pp. 1556-1563 [ Pubmed: 37845322 DOI: doi:10.1038/s41563-023-01683-1 ]
- O32-zl4 component a (8 kDa, Protein from synthetic construct)
- O32-zl4 (764 kDa, Complex from Thermotoga maritima)
- Sodium ion (22 Da, Ligand)
- O32-zl4 component b (23 kDa, Protein from Thermotoga maritima)
Cryo-EM structure of designed Influenza HA binder, HA_20, bound to Influenza HA (Strain: Iowa43)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8sk7
Q-score: 0.528
Watson JL, Juergens D, Bennett NR, Trippe BL, Yim J, Eisenach HE, Ahern W, Borst AJ, Ragotte RJ, Milles LF, Wicky BIM, Hanikel N, Pellock SJ, Courbet A, Sheffler W, Wang J, Venkatesh P, Sappington I, Torres SV, Lauko A, De Bortoli V, Mathieu E, Ovchinnikov S, Barzilay R, Jaakkola TS, DiMaio F, Baek M, Baker D
Nature (2023) 620 pp. 1089-1100 [ Pubmed: 37433327 DOI: doi:10.1038/s41586-023-06415-8 ]
- Influenza ha (iowa43) bound to rfdiffusion designed minibinder, ha_20 (Complex from Influenza A virus)
- Ha_20 minibinder (rfdiffusion-designed) (7 kDa, Protein from synthetic construct)
- Hemagglutinin ha1 chain (35 kDa, Protein from Influenza A virus)
- Hemagglutinin (26 kDa, Protein from Influenza A virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Top-down design of protein architectures with reinforcement learning
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8f4x
Q-score: 0.484
Lutz ID, Wang S, Norn C, Courbet A, Borst AJ, Zhao YT, Dosey A, Cao L, Xu J, Leaf EM, Treichel C, Litvicov P, Li Z, Goodson AD, Rivera-Sanchez P, Bratovianu AM, Baek M, King NP, Ruohola-Baker H, Baker D
Science (2023) 380 pp. 266-273 [ Pubmed: 37079676 DOI: doi:10.1126/science.adf6591 ]
- Rc_i_1-h11 (Complex from Escherichia coli)
- Rc_i_1-h11 (7 kDa, Protein from synthetic construct)
Top-down design of protein architectures with reinforcement learning
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8f53
Q-score: 0.555
Lutz ID, Wang S, Norn C, Courbet A, Borst AJ, Zhao YT, Dosey A, Cao L, Xu J, Leaf EM, Treichel C, Litvicov P, Li Z, Goodson AD, Rivera-Sanchez P, Bratovianu AM, Baek M, King NP, Ruohola-Baker H, Baker D
Science (2023) 380 pp. 266-273 [ Pubmed: 37079676 DOI: doi:10.1126/science.adf6591 ]
- Rc_i_2 (Complex from Escherichia coli)
- Rc_i_2 (5 kDa, Protein from synthetic construct)
Top-down design of protein architectures with reinforcement learning
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8f54
Q-score: 0.61
Lutz ID, Wang S, Norn C, Courbet A, Borst AJ, Zhao YT, Dosey A, Cao L, Xu J, Leaf EM, Treichel C, Litvicov P, Li Z, Goodson AD, Rivera-Sanchez P, Bratovianu AM, Baek M, King NP, Ruohola-Baker H, Baker D
Science (2023) 380 pp. 266-273 [ Pubmed: 37079676 DOI: doi:10.1126/science.adf6591 ]
- Rc_i_1 (7 kDa, Protein from synthetic construct)
- Rc_i_1 (Complex from Escherichia coli)