Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8quc
Q-score: 0.551
Liang Q, Chi G, Cirqueira L, Zhi L, Marasco A, Pilati N, Gunthorpe MJ, Alvaro G, Large CH, Sauer DB, Treptow W, Covarrubias M
Nat Commun (2024) 15 pp. 2533-2533 [ DOI: doi:10.1038/s41467-024-46813-8 Pubmed: 38514618 ]
- Potassium voltage-gated channel subfamily c member 1 (58 kDa, Protein from Homo sapiens)
- (5r)-5-ethyl-3-[6-(3-methoxy-4-methyl-phenoxy)pyridin-3-yl]imidazolidine-2,4-dione (341 Da, Ligand)
- Homotetramer of human kv3.1a with modulator aut1 (240 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8qud
Q-score: 0.555
Liang Q, Chi G, Cirqueira L, Zhi L, Marasco A, Pilati N, Gunthorpe MJ, Alvaro G, Large CH, Sauer DB, Treptow W, Covarrubias M
Nat Commun (2024) 15 pp. 2533-2533 [ DOI: doi:10.1038/s41467-024-46813-8 Pubmed: 38514618 ]
- Potassium voltage-gated channel subfamily c member 1 (58 kDa, Protein from Homo sapiens)
- Homotetramer of human kv3.1a with modulator aut5 (240 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- (5r)-5-ethyl-3-(6-spiro[2h-1-benzofuran-3,1'-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione (365 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
Human voltage-gated potassium channel Kv3.1 (apo condition)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7phh
Q-score: 0.485
Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, Covarrubias M, Durr KL
Nat Commun (2022) 13 pp. 4087-4087 [ Pubmed: 35840580 DOI: doi:10.1038/s41467-022-29594-w ]
- Homotetrameric complex of human kv3.1 (Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Potassium voltage-gated channel, shaw-related subfamily, member 1 (58 kDa, Protein from Homo sapiens)
Human voltage-gated potassium channel Kv3.1 (with Zn)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7phi
Q-score: 0.476
Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, Covarrubias M, Durr KL
Nat Commun (2022) 13 pp. 4087-4087 [ Pubmed: 35840580 DOI: doi:10.1038/s41467-022-29594-w ]
- Homotetrameric complex of human kv3.1 (Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Potassium voltage-gated channel, shaw-related subfamily, member 1 (58 kDa, Protein from Homo sapiens)
Human voltage-gated potassium channel Kv3.1 in dimeric state (with Zn)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7phk
Q-score: 0.381
Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, Covarrubias M, Durr KL
Nat Commun (2022) 13 pp. 4087-4087 [ Pubmed: 35840580 DOI: doi:10.1038/s41467-022-29594-w ]
- Homotetrameric complex of human kv3.1 (Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Potassium voltage-gated channel, shaw-related subfamily, member 1 (58 kDa, Protein from Homo sapiens)
Human voltage-gated potassium channel Kv3.1 (with EDTA)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7phl
Q-score: 0.493
Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, Covarrubias M, Durr KL
Nat Commun (2022) 13 pp. 4087-4087 [ Pubmed: 35840580 DOI: doi:10.1038/s41467-022-29594-w ]
- Homotetrameric complex of human kv3.1 (Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Potassium voltage-gated channel, shaw-related subfamily, member 1 (58 kDa, Protein from Homo sapiens)