Structure of the EVA71 strain 11316 capsid
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 6uh1
Q-score: 0.469
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ DOI: doi:10.1021/acs.jmedchem.9b01737 Pubmed: 31809045 ]
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Enterovirus a71 (Virus from Enterovirus A71)
EV-A71 strain 11316 complexed with MADAL compound 22
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 6uh6
Q-score: 0.441
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ DOI: doi:10.1021/acs.jmedchem.9b01737 Pubmed: 31809045 ]
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Enterovirus a71 (Virus from Enterovirus A71)
- Vp2 (26 kDa, Protein from Enterovirus A71)
EV-A71 strain 11316 complexed with MADAL compound 30
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 6uh7
Q-score: 0.468
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ DOI: doi:10.1021/acs.jmedchem.9b01737 Pubmed: 31809045 ]
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Enterovirus a71 (Virus from Enterovirus A71)
Identification of a druggable VP1-VP3 interprotomer pocket in the capsid of enteroviruses
Abdelnabi R, Geraets JA, Ma Y, Mirabelli C, Flatt JW, Domanska A, Delang L, Jochmans D, Kumar TA, Jayaprakash V, Sinha BN, Leyssen P, Butcher SJ, Neyts J
PLoS Biol. (2019) 17 [ Pubmed: 31185007 DOI: 10.1371/journal.pbio.3000281 ]
Image sets:
Identification of a druggable VP1-VP3 interprotomer pocket in the capsid of enteroviruses
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6gzv
Q-score: 0.454
Abdelnabi R, Geraets JA, Ma Y, Mirabelli C, Flatt JW, Domanska A, Delang L, Jochmans D, Kumar TA, Jayaprakash V, Sinha BN, Leyssen P, Butcher SJ, Neyts J
PLoS Biol (2019) 17 pp. e3000281-e3000281 [ Pubmed: 31185007 DOI: doi:10.1371/journal.pbio.3000281 ]
- Capsid protein vp1 (31 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- Coxsackievirus b3 (strain nancy) (Virus from Coxsackievirus B3 (strain Nancy))
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- Capsid protein vp3 (26 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- Capsid protein vp2 (28 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- 4-[[4-[1,3-bis(oxidanylidene)isoindol-2-yl]phenyl]sulfonylamino]benzoic acid (422 Da, Ligand)
Structure of the EVA71 strain 11316 capsid
Sun L, Lee H, Thibaut HJ, Lanko K, Rivero-Buceta E, Bator C, Martinez-Gualda B, Dallmeier K, Delang L, Leyssen P, Gago F, San-Felix A, Hafenstein S, Mirabelli C, Neyts J
PLoS Pathog (2019) 15 pp. e1007760-e1007760 [ DOI: doi:10.1371/journal.ppat.1007760 Pubmed: 31071193 ]
- Vp2 (26 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
EV-A71 strain 11316 complexed with tryptophan dendrimer MADAL_0385
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 6diz
Q-score: 0.509
Sun L, Lee H, Thibaut HJ, Lanko K, Rivero-Buceta E, Bator C, Martinez-Gualda B, Dallmeier K, Delang L, Leyssen P, Gago F, San-Felix A, Hafenstein S, Mirabelli C, Neyts J
PLoS Pathog (2019) 15 pp. e1007760-e1007760 [ DOI: doi:10.1371/journal.ppat.1007760 Pubmed: 31071193 ]
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Vp4 (8 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
- Vp2 (26 kDa, Protein from Enterovirus A71)