Structure of the EVA71 strain 11316 capsid
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 6uh1
Q-score: 0.469
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ Pubmed: 31809045 DOI: doi:10.1021/acs.jmedchem.9b01737 ]
- Sphingosine (299 Da, Ligand)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
EV-A71 strain 11316 complexed with MADAL compound 22
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 6uh6
Q-score: 0.441
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ DOI: doi:10.1021/acs.jmedchem.9b01737 Pubmed: 31809045 ]
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Enterovirus a71 (Virus from Enterovirus A71)
- Vp2 (26 kDa, Protein from Enterovirus A71)
EV-A71 strain 11316 complexed with MADAL compound 30
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 6uh7
Q-score: 0.468
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ Pubmed: 31809045 DOI: doi:10.1021/acs.jmedchem.9b01737 ]
- Sphingosine (299 Da, Ligand)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
Identification of a druggable VP1-VP3 interprotomer pocket in the capsid of enteroviruses
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6gzv
Q-score: 0.454
Abdelnabi R, Geraets JA, Ma Y, Mirabelli C, Flatt JW, Domanska A, Delang L, Jochmans D, Kumar TA, Jayaprakash V, Sinha BN, Leyssen P, Butcher SJ, Neyts J
PLoS Biol (2019) 17 pp. e3000281-e3000281 [ Pubmed: 31185007 DOI: doi:10.1371/journal.pbio.3000281 ]
- Capsid protein vp1 (31 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- Coxsackievirus b3 (strain nancy) (Virus from Coxsackievirus B3 (strain Nancy))
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- Capsid protein vp3 (26 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- Capsid protein vp2 (28 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- 4-[[4-[1,3-bis(oxidanylidene)isoindol-2-yl]phenyl]sulfonylamino]benzoic acid (422 Da, Ligand)
Structure of the EVA71 strain 11316 capsid
Sun L, Lee H, Thibaut HJ, Lanko K, Rivero-Buceta E, Bator C, Martinez-Gualda B, Dallmeier K, Delang L, Leyssen P, Gago F, San-Felix A, Hafenstein S, Mirabelli C, Neyts J
PLoS Pathog (2019) 15 pp. e1007760-e1007760 [ DOI: doi:10.1371/journal.ppat.1007760 Pubmed: 31071193 ]
- Sphingosine (299 Da, Ligand)
- Vp2 (26 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
EV-A71 strain 11316 complexed with tryptophan dendrimer MADAL_0385
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 6diz
Q-score: 0.509
Sun L, Lee H, Thibaut HJ, Lanko K, Rivero-Buceta E, Bator C, Martinez-Gualda B, Dallmeier K, Delang L, Leyssen P, Gago F, San-Felix A, Hafenstein S, Mirabelli C, Neyts J
PLoS Pathog (2019) 15 pp. e1007760-e1007760 [ DOI: doi:10.1371/journal.ppat.1007760 Pubmed: 31071193 ]
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Vp4 (8 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
- Vp2 (26 kDa, Protein from Enterovirus A71)