Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Native eisosome lattice bound to plasma membrane microdomain
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8qb7
Q-score: 0.323
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Resolution: 3.35 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qb9
Q-score: 0.478
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Resolution: 3.86 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qbb
Q-score: 0.404
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
- Helical assembly of recombinant pil1 protein tubulating +pip2/-sterol lipid mixture (dopc,dope,dops,pi(4,5)p2 50:20:20:10) (Complex from Saccharomyces cerevisiae)
- D-myo-inositol-1,4,5-triphosphate (420 Da, Ligand)
- Sphingolipid long chain base-responsive protein pil1 (38 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 3.61 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qbd
Q-score: 0.428
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
- D-myo-inositol-1,4,5-triphosphate (420 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Helical assembly of recombinant pil1 protein tubulating +pip2/+sterol lipid mixture (dopc, dope, dops, cholesterol, pi(4,5)p2 35:20:20:15:10) (Complex from Saccharomyces cerevisiae)
- Sphingolipid long chain base-responsive protein pil1 (38 kDa, Protein from Saccharomyces cerevisiae)
Compact state - Native eisosome lattice bound to plasma membrane microdomain
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8qbe
Q-score: 0.228
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Stretched state - Native eisosome lattice bound to plasma membrane microdomain
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8qbg
Q-score: 0.217
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
ACAD9-WT in complex with ECSIT-CTER
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8phe
Q-score: 0.551
McGregor L, Acajjaoui S, Desfosses A, Saidi M, Bacia-Verloop M, Schwarz JJ, Juyoux P, von Velsen J, Bowler MW, McCarthy AA, Kandiah E, Gutsche I, Soler-Lopez M
Nat Commun (2023) 14 pp. 8248-8248 [ DOI: doi:10.1038/s41467-023-43865-0 Pubmed: 38086790 ]
- Complex i assembly factor acad9, mitochondrial (65 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Evolutionarily conserved signaling intermediate in toll pathway, mitochondrial (25 kDa, Protein from Homo sapiens)
- Acad9 wt in complex with ecsit cter (180 kDa, Complex from Homo sapiens)
Cryo-EM structure of human ACAD9-S191A
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8phf
Q-score: 0.418
McGregor L, Acajjaoui S, Desfosses A, Saidi M, Bacia-Verloop M, Schwarz JJ, Juyoux P, von Velsen J, Bowler MW, McCarthy AA, Kandiah E, Gutsche I, Soler-Lopez M
Nat Commun (2023) 14 pp. 8248-8248 [ DOI: doi:10.1038/s41467-023-43865-0 Pubmed: 38086790 ]
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Complex i assembly factor acad9, mitochondrial (65 kDa, Protein from Homo sapiens)
- Acad9 s191a (120 kDa, Complex from Homo sapiens)
McGregor L, Acajjaoui S, Desfosses A, Saidi M, Bacia-Verloop M, Schwarz JJ, Juyoux P, von Velsen J, Bowler MW, McCarthy AA, Kandiah E, Gutsche I, Soler-Lopez M
Nat Commun (2023) 14 pp. 8248-8248 [ DOI: doi:10.1038/s41467-023-43865-0 Pubmed: 38086790 ]
- Acad9 wt (Protein from Homo sapiens)
- Acad9 wt (120 kDa, Complex from Homo sapiens)